Protocol summary

Summary
To assess the outcome and safety of the totally tubeless percutaneous nephrolithotomy (PCNL) in compare with standard PCNL in the children under 14 years old. Twenty three patients with upper pole renal stones were enrolled in a prospective randomized clinical trial during July 2010 to Jan 2012. The inclusion criteria were patient age less than 14 years old; existence of stone size >2.5 cm; stone resistant to the extracorporeal shockwave lithotripsy (SWL); furthermore, exclusion criteria were serious bleeding; perforation in the collecting system during the operation; kidney anomalies; renal failure on admission. The patients were divided into two groups. Totally tubeless percutaneous nephrolithotomy was performed on one group while, patients in another group underwent standard procedure. The incidence of complications, hospital stay, transfusion rate, stone free rate and analgesic use were compared between the two groups during a 1-month study period.

General information

Acronym
IRCT registration information
IRCT registration number: IRCT201110017675N1
Registration date: 2011-10-08, 1390/07/16
Registration timing: registered_while_recruiting

Last update:
Update count: 0
Registration date
2011-10-08, 1390/07/16
Registrant information
Name
Mehdi Aloosh
Name of organization / entity
Tehran University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 21 6634 8556
Email address
m_aloosh@farabi.tums.ac.ir
Recruitment status
Recruitment complete
Funding source
Vice chancellor for research, Tehran University of Medical Sciences
Expected recruitment start date
2010-07-01, 1389/04/10
Expected recruitment end date
2011-12-31, 1390/10/10
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Comparing efficacy and safety of conventional and totally tubeless percutaneous nephrolithotomy in under 14 year-old patients; a clinical trial
Public title
Comparing efficacy and safety of conventional and totally tubeless percutaneous nephrolithotomy in under 14 year-old patients; a clinical trial
Purpose
Treatment
Inclusion/Exclusion criteria
The inclusion criteria were patient age less than 14 years old; the existence of stone size >2.5 cm; stone resistant to extracorporeal shockwave lithotripsy (SWL). The exclusion criteria were serious bleeding; perforation in the collecting system during the operation; kidney anomalies; renal failure on admission.
Age
To 14 years old
Gender
Both
Phase
2
Groups that have been masked
No information
Sample size
Target sample size: 20
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Single blinded
Blinding description
Placebo
Not used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Tehran University of Medical Sciences' ethical committee
Street address
Tehran University of Medical Sciences, Enghelab St.
City
Tehran
Postal code
Approval date
2011-09-10, 1390/06/19
Ethics committee reference number
14418

Health conditions studied

1

Description of health condition studied
Kidney stone
ICD-10 code
N20.0
ICD-10 code description
Calculus of kidney

Primary outcomes

1

Description
postoperative analgesic requirement
Timepoint
after surgery till discharge
Method of measurement
mg of morphine use

2

Description
hospitalization period
Timepoint
after surgery till discharge
Method of measurement
days of hospitalization

Secondary outcomes

1

Description
operation time
Timepoint
time of surgery
Method of measurement
minutes of surgery

2

Description
Hemoglobin changes
Timepoint
during surgery till discharge
Method of measurement
mg/dl of Hemoglobin

3

Description
need to re-operation
Timepoint
after surgery, 1 week and 1 month later
Method of measurement
need to re-operation

Intervention groups

1

Description
intervention: Totally tubeless percutaneous nephrolithotomy
Category
Treatment - Surgery

2

Description
control: standard percutaneous nephrolithotomy
Category
Treatment - Surgery

Recruitment centers

1

Recruitment center
Name of recruitment center
Urology department, Sina hospital
Full name of responsible person
Alborz Salavati
Street address
Urology department, Sina hospital, Hasan abad Sq.
City
Tehran

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Vice chancellor for research, Tehran University of Medical Sciences
Full name of responsible person
Dr. Fotoohi
Street address
4th Floor, Centeral Building of Tehran University of Medical Sciences, Ghods St, Keshavarz Av.
City
Tehran
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Vice chancellor for research, Tehran University of Medical Sciences
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty

Person responsible for general inquiries

Contact
Name of organization / entity
Tehran University of Medical Sciences
Full name of responsible person
Mehdi Aloosh
Position
Researcher /MD
Other areas of specialty/work
Street address
Research Development Center, Sina hospital, Hasan Abad Sq.
City
Tehran
Postal code
Phone
+98 21 6634 8556
Fax
Email
m_aloosh@farabi.tums.ac.ir
Web page address

Person responsible for scientific inquiries

Contact
Name of organization / entity
Tehran University of Medical Sciences
Full name of responsible person
Seyyed Mohammad Kazem Aghamir
Position
Associated Professor/ MD
Other areas of specialty/work
Street address
Urology department, Sina Hospital, Hasan Abad Sq.
City
Tehran
Postal code
Phone
+98 21 6634 8556
Fax
Email
m_aloosh@farabi.tums.ac.ir; smkaghamir@yahoo.com
Web page address

Person responsible for updating data

Contact
Name of organization / entity
Tehran University of Medical Sciences
Full name of responsible person
Alborz Salavati
Position
urology resident
Other areas of specialty/work
Street address
Urology department, Sina hospital, Hasan Abad Sq.
City
Tehran
Postal code
Phone
+98 21 6634 8556
Fax
Email
alborz234@yahoo.com; md_aloosh@hotmail.com
Web page address

Sharing plan

Deidentified Individual Participant Data Set (IPD)
empty
Study Protocol
empty
Statistical Analysis Plan
empty
Informed Consent Form
empty
Clinical Study Report
empty
Analytic Code
empty
Data Dictionary
empty
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