Determination and comparison of the effects of intraperitoneal bupivacaine, morphine and dexamethasone on postoperative pain in women 20 to 45 years old undergoing elective cesarean section with general anesthesia

The aim of this study is to determine and compare the effects of intraperitoneal administration of bupivacaine, morphine and dexamethasone on post cesarean section pain control. This is an interventional, single-center, controlled with placebo and randomized study on 144 pregnant women 20 to 45 years old with American Society of Anesthesia( ASA) class І and II, who candidate for elective cesarean section. Emergency cases, individuals with history of opioid addiction, and chronic pain syndrome were excluded. This study is double-blinded. Anesthesiology resident and patients do not inform about kinds of drugs. Patients were randomly divided into four groups (n= 36) on the basis of selection of colored cards. All patients underwent General anesthesia with similar method. At the end of surgery in group one 30 cc of bupivacaine 0.025% and in group two 16 mg of dexamethasone that was diluted to 30 cc and in group three 5mg of morphine that was diluted to 30 cc and in control group 30 cc of saline was poured intraperitonealy by the surgeon. Postoperative pain was recorded with the use of a visual analog scale with scores ranging from 1 to 10 at 2, 4 and 6 h intervals after the surgery. Analgesia requirements, vital signs (blood pressure and heart rate) and incidence of nausea and vomiting were also recorded. Additional analgesics (intravenous meperidine 0.5 mg / kg) was administered to the patients with visual analog scale more than 3 in the postoperative period.

Vice Chancellor for research of Qazvin University of Medical Sciences