Objectives: To investigate the role of an alternative carbohydrate diet on glycemic control, we intend to explore the effect of a low glycemic load (Low GL)-high fat diet on glycemic response and also glycated hemoglobin (HbA1c) of poor-controlled diabetes patients.
Design: The project is "before and after" study in one group and each subject is him/her control.
Inclusive and exclusive criteria: The inclusive criteria are: men and women with age of 30-60 years, BMI> 25, HbA1c > 8% and the exclusive criteria includes: patients having renal, heart, gastro-intestinal disorders, chronic disease, pregnant and nursing mothers.
Setting and conduct: Hundred poorly-controlled diabetes patients, HbA1c > 8% who are referred to endocrine clinic in city of Qazvin and are consuming traditional medium carbohydrate diabetic diet will be recruited for the study. Fasting blood samples for biochemical analysis will be taken and weight and BMI will be recorded at the beginning and after a-10 week diet intervention. Patients will have their routine life style program during intervention. The mean of the data before and after intervention will be compared using paired t-test
Intervention: A low GL diet (Energy 1800-2200 kcal; total fat 36%; fat derived from olive oil and nuts 15%; carbohydrate 42%; protein 22%) will be administrated to patients for 10 weeks
Main outcome measures: Fasting blood glucose, HbA1c, triglyceride, cholesterol (LDL, HDL), Body weight, and BMI changes of patients will be measured, comparing related data of before and after intervention.