We studied effect of Clofazimine on cutaneous leishmaniasis to find new and easier way in treatment of the disease. Twenty four patients was selected from patients that referred to Shahid-Faghihi Hospital during 22 September 2007 to 5 December 2008. Patients received Clofazimine 50 -100 mg/day according to weight of patient for 3 weeks. Inclusion criteria: age more than 12 y/o, duration of disease less than 2month, no anti-leishmanial treatment(Glucantim, Rifampin, Azithromycin) since 1month prior to study, Exclusion criteria: pregnancy, lactation, severe diseases including; hepatic, respiratory and renal disease. Lesion of patients scored according to size, indurations, erythema and ulceration at the baseline, end of treatment period and end of the study (weeks 0, 3, and 6 respectively). We considered one point of score for 5mm of each of these indices and defined as a number. The sum of these numbers was considered as patient's score. Treatment was defined as complete re-epithelialization of lesion, partial treatment as more than 60% improvement in the score of lesions and failure of treatment was considered as improvement of score equal or less than 60%.