Comparison of adding dexmedetomidine with fentanyl، to acetaminophen in intravenous patient controlled analgesia (PCA)، for pain after Caesarean section

The purpose of this research is survey of the effectiveness of intravenous infusion pump combined with( dexmedetomidine and acetaminophen ) compared with( fentanyl and acetaminophen ) for postoperative pain control in patients who have undergone cesarean section. Inclusion criteria: Parturient with age between 20 and 38 years who come to Rasool e Akram hospital and cesarean under neuroaxial(spinal or epidural) anesthesia and Exclusion criteria: Dissatisfaction and history of opioid analgesic use or tranquilliser use.60 individuals alternatively allocate to Group A and Group B .In Group A PCIA protocol consisted of 2g Acetaminophen and fentanyl (0.3 mic.g./kg/min for24h)diluted into 100 ml with physiological saline and administered at a continuous infusion rate of 4 ml/h. In Group B PCIA protocol consisted of 2g Acetaminophen and dexmedetomidine(0.15 mic.g./kg/h for24h)diluted into 100 ml with physiological saline and administered at a continuous infusion rate of 4 ml/h.Then Visual Analogue Scale and vital signs evaluate after 1, 6, 12 , 24 h for the first 24 h. postoperatively.All patients receive 25mg pethidine for postoperative analgesia if VAS was more than 3. Bradycardia define HR(Heart Rate) more than 20% decline from the baseline and Hypotension define MBP(Mean Blood Pressure) more than 20% decline from the baseline. Bradycardia was treated with intravenous Atropine(0.02mg/kg) and Hypotension was treated with intravenous Ephedrine(0.1mg/kg). Side effects and satisfaction is evaluated for 24 h after surgery.

Vice Chancellor for Research and Technology of IRAN University of Medical Sciences