Comparison of the effects of oral and intravenous acetylcysteine ​​in treating acetaminophen poisoning in admitted patients to poisoning emergency ward of Baharloo Hospital (2011-2012)

This study is double blind randomized control trial in phase 4. Study population is referred patients to baharloos’ hospital toxicological emergency ward. Samples allocated by randomized block sampling method in two standard (20-hour intravenous NAC protocol is 150 mg/kg loading dose over 15 minutes, followed by an additional dose of 50 mg/kg over 4 hours, and then 100 mg/kg over 16 hours, for a total dose 300 mg/kg) and experimental group (The 72-hour oral regimen is a 140-mg/kg loading dose followed by 70 mg/kg for 17 additional doses, for a total dose of 1330 mg/kg. Inclusion criteria: Patients over 18 year’s old age which consume 7.5 gr acetaminophen during 24 hr ago will be concluding in the study. Exclusion criteria: Admission after 24 hr after consumption of acetaminophen, co ingestion of cholinergic drugs, primary unconsciousness, primary hepatic encephalopathy, presence of status epilepticus after NAC therapy, history of asthma and anaphylactoid reactions will considering as exclusion criteria. Acetaminophen serum concentration measured in the first of the study. Liver enzyme including AST, ALT and Prothrombin measured in the first of the study and for 72 hour Created complications and therapeutic effect will record and will compare by means of statistical analysis. Study duration is one-year from January 2012 to December 2012.

Vice chancellor of Research, Tehran University of Medical Sciences