This randomized, triple-blind clinical trial is with placebo control group, that is performing following the approval by the ethics committee of Shahid Beheshti University of Medical Sciences, International Branch, Tehran, Iran, In doing so, the researcher visit the students in
their separate rooms, introduce herself and explaine the objectives
of the study, and invite them to cooperate in the survey.Then students whom being
single, age within 18e35 years, normal body mass index, regular
menstrual cycle (21e35 days), with diagnosed PMS, no physical or
psychological ill conditions, not on medication (hormonal, vitamins,
herbal, antidepressant, aspirin, or warfarin), no history of
allergy to herbal drugs, no sad event occurrence, no surgical
operation during the last six months, not being a professional
athlete, presence of at least five symptoms based on DSM-IV
(Diagnostic and Statistical Manual of Mental Disorders-fourth edition) for PMS diagnosis with confirmed one symptom out of the
first four symptoms including (1. Feeling sad, hopeless or selfdeprecating,
2. Feeling tense, anxious, or “on edge”, 3. Marked liability
of mood, interspersed with frequent tearfulness, 4. Persistent
irritability, anger and increased interpersonal conflicts, 5.
Decreased interest in usual activities that may be associated with
withdrawal from social relationships), not being depressed based
on Beck questionnaire. Those with the above mentioned criteria
were entered into the study. An informed written consent was also
given by each participant.PMS daily form: The participants filled the daily form of PMS
consisting of 30 items on the symptoms divided into 15 physical
ones including breast tenderness, headache, vertigo, bloating,
weight gain, swollen extremities, palpitation, arthralgia and
myalgia, sweating and chills, change in bowel movement,
nausea, acne, recurrent herpes like infection, flushing and hotness,
pelvic and abdominal pains and lassitude, fatigue and low
energy state and 15 psychological, emotional and behavioral
ones consisting of depression, anxiety, tension, emotional and
affective instability, anger, irritability, loss of interest in daily
routine activities, difficulty in concentration, forgetfulness, unjustified
tendency to cry, avoiding socialization and contacts,
preference for solitude, feeling of being out of control, change in
sleeping pattern, change in appetite or overeating, desire to eat
sweets and salt, and tendency to commit suicide.In doing so, the mean of severity was obtained
and converted into percentage. Based on the percentages, the
participants were divided into three groups; those with mild
symptoms (below 33%), medium group (between 33% and 66%),
and severe group (above 66%).then with using Eexel Software divided into two 45 person groups. And after obtaining the written consent of their medicines (45 person 3 capsules daily intake of 500 mg sage and 45 person 3 capsules of intake placebo) will be provided.