Comparison between intravenous morphine versus fentanyl efficacy in acute pain relief in drug abuser patients with pain due to acute limb traumatic injury

Objective Comparison between intravenous morphine versus fentanyl efficacy in acute pain relief in drug abuser patients with pain due to acute limb traumatic injury Inclusion criteria All patients with traumatic limb pain who are above 18 and have history of opioid addiction enrolled in the study. Exclusion criteria Patients with decreased level of consciousness and history of opioid drug consumption after traumatic injury excluded from the study study population All traumatic limb patients who come to the emergency department of Sina and Shariati Hospital during the study period Sample size Calculated sample size is 320 patients in both group of the study, 160 cases and 160 control patients Interventions and primary outcome This randomized double blind study will conduct in emergency departments of Shariati and Sina Hospitals of Tehran.After signing of informed consent form and explaining the nature of study should determine their pain level score according to VAS. Then patients randomly assigned to each group of study. Group A receive intravenous morphine sulfate 0.1 mg/kg (morphine 10 mg/cc, Daru Pakhsh, Tehran, Iran) and group b receive fentanyl hydro-chloride 1 µg/kg(fentanyl, 500µg/10cc, abureyhan, Tehran, Iran). Vas score should checked before drug administration and 5, 15, 30, and 60 min after drug administration in both groups. In both group of the study if pain level reduced less than 13 mm after drug administration( morphine or fentanyl) in 5 min after drug administration the rescue dose should be considered.

deputy of research of Tehran University of Medical Sciences