Postoperative pain control is a clinical challenge. Many methods have been proposed to reduce pain after surgery. Today, many pharmaceutical drugs such as pregabalin more common after surgery. The purpose of this study was to investigate the effect of different doses of pregabalin before and after laparoscopic hysterectomy to prevent pain from the surgery. The results of this study will be to determine the optimal dose.
In this clinical blind randomized placebo-controlled study, 70 women 30 to 65 years, candidates for hysterectomy laparoscopic with ASA physical status I-II, without long analgesics consumption or experience chronic pelvic pain were selected and will be classified into one of 4 groups: placebo, group therapy 75 mg, 150 mg and 300 mg.
For mentioned treatment groups, the night before, half an hour before the operation and also 6 hours after surgery, according to given category, pregabalin capsules 75, 150 and 300 mg and for the control group in the same way, the placebo will be administered.
Then, the mean pain by visual analog scale, side effects, nausea and vomiting after surgery, narcotic dose (pethidine) and conscious level of patients under study, will be evaluated and recorded.