The aim of this clinical trial is comparison the efficacy of 10% garlic extract and Cryotherapy in treatment of genital warts in men. For evaluation a new effective and low cost treatment and less side effects. 33 male patients referred to dermatology clinic of Imam hospital in Ahvaz with genital warts were enrolled. The informed consent was taken from all patients who enrolled in the study. The inclusion criteria includes: clinically diagnosed genital warts and have more than two warts on both sides of genital region. Excluding criteria includes: past history of sensitivity to garlic. Diagnosis was made by two dermatologists. In ambiguous cases a biopsy was taken. Demographic data on age, duration of disease, size and number of lesions were recorded. Cryotherapy with- 196◦ temperature liquid nitrogen was performed for all right sided warts and garlic extract 10% was applied on all left-sided warts. A cotton swab immersed in garlic extract was applied for 10 seconds on left side lesions. Garlic extract was prepared by pharmacy school of Jundishapur University of Medical Sciences. cryotherapy was applied every two weeks. Participants were trained to self apply garlic extract twice a day with a cotton swab. They were visited every two weeks up to 8 weeks. Before, during and at the end of study photography was taken by camera (canon, 5megapixcel) at a thirty centimeter distance and full face. At the end of 8th week data on both groups were analyzed.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT201202138992N1
Registration date:2012-05-27, 1391/03/07
Registration timing:retrospective
Last update:
Update count:0
Registration date
2012-05-27, 1391/03/07
Registrant information
Name
Abolfath Mehrabian
Name of organization / entity
Jundishapur University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 61 1292 1837
Email address
mehrabian.a@ajums.ac.ir
Recruitment status
Recruitment complete
Funding source
Ahvaz Jundishapur University of Medical Sciences
Expected recruitment start date
2011-03-13, 1389/12/22
Expected recruitment end date
2011-09-13, 1390/06/22
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Comparison of the efficacy of garlic extracts 10% and cryotherapy (liquid nitrogen) in the treatment of the genital warts in men.
Public title
The efficacy of cryotherapy versus garlic extract 10%in the treatment of genital warts in men.
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria :men; more than two warts on both sides of genital region
Exclusion criteria: patients with past history sensitivity to garlic.
Age
No age limit
Gender
Male
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
33
Randomization (investigator's opinion)
N/A
Randomization description
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Jundishapur University of Medical Sciences
Street address
Ahvaz Jundishapur University of Medical Sciences
City
Ahvaz
Postal code
Approval date
2011-03-12, 1389/12/21
Ethics committee reference number
EPH129
Health conditions studied
1
Description of health condition studied
Genital wart
ICD-10 code
A63.0
ICD-10 code description
Anogenital (venereal) warts
Primary outcomes
1
Description
Genital warts
Timepoint
2 weeks
Method of measurement
Number of genital warts
Secondary outcomes
1
Description
Contact dermatitis
Timepoint
2 weeks
Method of measurement
Paients report &observer
Intervention groups
1
Description
A cotton swab immersed in10% garlic extract was applied for 10 seconds on left side lesions twice daily for 8 weeks by the patients.
Category
Treatment - Drugs
2
Description
Cryotherapy with- 196◦ temperature liquid nitrogen by the open spray method was applied every two weeks up to 8 weeks and appearance of 1-1.5 mm freezed margin was considered the end of Procedure.
Category
Treatment - Other
Recruitment centers
1
Recruitment center
Name of recruitment center
Imam Khomeini Hospital
Full name of responsible person
Abolfath Mehrabian
Street address
Imam Khomeini Hospital، Ahvaz، Iran
City
Ahwaz
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Jundishapur University of Medical Sciences
Full name of responsible person
Mostafa Feghhi
Street address
Jundishapur University of Medical Sciences
City
Ahvaz
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Jundishapur University of Medical Sciences
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Jundishapur University of Medical Sciences
Full name of responsible person
Abolfath Mehrabian
Position
Resident of Dermatology
Other areas of specialty/work
Street address
Imam Hospital
City
Ahvaz
Postal code
Phone
+98 61 1292 1837
Fax
+98 61 1292 1837
Email
mehrabian.a@ajums.ac.ir
dr_mehrabian@ymail.com
Web page address
Person responsible for scientific inquiries
Contact
Name of organization / entity
Ahvaz Jundishapur University of Medical Sciences
Full name of responsible person
Abolfath Mehrabian
Position
Resident of Dermatology
Other areas of specialty/work
Street address
Imam Hospital
City
Ahvaz
Postal code
Phone
+98 61 1292 1837
Fax
+98 61 1292 1837
Email
mehrabian.a@ajums.ac.ir
dr_mehrabian@ymail.com
Web page address
Person responsible for updating data
Contact
Name of organization / entity
Ahvaz Jundishapur University of Medical Sciences
Full name of responsible person
Abolfath Mehrabian
Position
Resident of Dermatology
Other areas of specialty/work
Street address
Imam Hospital
City
Ahvaz
Postal code
Phone
+98 61 1292 1837
Fax
+98 61 1292 1837
Email
mehrabian.a@ajums.ac.ir dr_mehrabian@ymail.com
Web page address
Sharing plan
Deidentified Individual Participant Data Set (IPD)