Objectives: To assess the sedative and anesthetic effect of hypnotism versus acetaminophen, methadone and fentanyl in aware and awake patient in ICU ward.
Design: a single blind randomized clinical trial.
Setting and conduct: The eligible patients who are hospitalized in ICU ward of Besat Hospital during the study period will be enrolled into the trial.
Inclusion criteria: age of 18 to 50 years; literate at least diploma; need mechanical ventilation with any reason.
Exclusion criteria: consciousness disorder; acid-base disorder; psychiatric disorders.
Intervention group: hypnotism for an hour three times a day for 24 hours.
Control group 1: Acetaminophen 1 g intravenous every 6 hours for 24 hours.
Control group 2: Methadone 2.5 mg subcutaneous every 8 hours for 24 hours.
Control group 3: Infusion of fentanyl 75 mg every 6 hours for 24 hours.
Primary outcome: (a) assessing agitation before intervention and 20, 40, 60 min and 1, 2, 6, 12, and 24 hours after intervention through physical examination; (b) assessing pain before intervention and 20, 40, 60 min and 1, 2, 6, 12, and 24 hours after intervention using VAS scale.
Secondary outcome: assessing adverse effect (hypotension, apnea, bradycardia) 20, 40, 60 min and 1, 2, 6, 12, and 24 hours after intervention through physical examination.
Randomization: The patients will be randomly assigned to intervention and control groups using block randomization.
Blinding: The physician who will examine the patients will not be aware of the intervention. Therefore, the trial will be run as single blind