This research to determine the effect of omega-3 and vitamin C in serum cortisol, CRP, TAC, MDA, IL-6 and depression score and the number of job errors in shift workers Tehran oil refinery Was designed. This study is a double-blind intervention study with a placebo control group and 2 months of intervention with omega-3[each capsule containing 180 mg EPA(eicosapantanoic acid) and 120 mg DHA(docosahezanoic acid)] and vitamin C(250mg ascorbic acid) alone and in combination on the above variables in rotational depressed shift worker in Tehran Refinery.In first Beck Depression Inventory and the general questioner in all workers at operational and firefighting sites(456 people) will be distributed. People have entry criteria and no exclusion criteria were enrolled into the study. Inclusion criteria depression score equal to or more than 10 of the 21 item questionnaire Beck (beck) was agree to participate in research out of the presence of disease (thyroid, kidney, liver, diabetes, heart Cardiovascular, cancer, hypertension) based on the contents of employment records of individuals, as a professional exercise, smoking, alcohol consumption, drug materials, drug, or over two weeks before the study and taking supplements and drugs for depression at 2 months ago of studyso 136 shift workers entered to intervention. Blood serum to measure these markers before and after intervention with 10-12 hours fasting in 7.30-8.30 the morning 8cc fasting blood can receive, 24 h food questionnaire data collected through interviews. be collected, diastolic blood pressure, weigh and high is measured to calculate BMI .During the study, subjects were asked not to change their diet. After explaining the study and how its implementation of all participants in the intervention, written consent was obtained for participation in research. For intervention research shift worker using a balanced block randomization method were divided into 4 groups. Omega-3 capsules and tablets appear to be different so, double-dummy technique was used in the study. In Group 1, 2 capsules omega-3 and 2 tablets of vitamin C and in Group 2, 2 capsules of omega-3 and 2 placebo tablet of vitamin C and group 3, 2 tablets of vitamin C and 2 placebo capsule of omega-3 in the group 4،2 placebo capsule of omega-3 and 2 placebo tablet of vitamin C for every day in 2 months. this study approved by Medical Ethics Medical School University took place in Tehran.