ketamine is used as analgesic for performing procedures in emergency departments especially for children. Vomiting is one the most common adverse effects of ketamine injection. The goal of this study was to determine the effect of ondansetron on ketamine related vomiting in children.
Children from 6months to 10years who will come to emergency deparment of Imam or Shariati hospital need procedural sedation analgesia, will randomly assigned to ketamine or ketamine plus ondansetron groups. Patients would exclude from the study, if they had any of exclusion criteria, such as allergy to ketamine or ondansetron, seizure, airway disease, head trauma, uncontrolled high blood pressure and vomiting before starting the process associated with other diseases, especially head trauma. Sample size determined at least 60 children in each groups, means totally 120 patients.
The first group will receive 4 mg /kg ketamine (intramuscular) and the second group will receive the same dose of ketamine plus ondansetron (0.1 mg /kg, up to 2 mg) in the same syringe. Level of sedation, vital signs including pulse rate and SpO2 and side effects especially nausea and vomiting will record during procedure, through recovery period and 4 hours after completion of the procedure.