Purpose: Comparison of intraoperative blood pressure and heart rate changes, postoperative nausea, vomiting and pain in two methods of epidural and general anesthesia in laparoscopic cholecystectomy. Design and criteria: This study is prospective, randomized, double-blinded and clinical trial. 66 patients candidate for laparoscopic cholecystectomy were chosen and divided randomly to same groups. For the first group, general anesthesia (GA) and for the second group, epidural anesthesia is used. Methods and interventions: After monitoring, in the first group anesthesia is induced with fentanyl 4μg/kg, 0.5mg/kg atracurium and propofol 2mg/kg and is maintained by propofol infusion, atracurium and fentanil if needed. In the second group, patients are placed in the sitting position and using a 18-gauge tuohy needle, 15 mL of 0.5% hyperbaric bupivacaine is injected in the epidural space and the catheter inserted. Primary and secondary outcome: Blood pressure and heart rate were recorded before induction, after intubation in Group A, after catheter insertion and change the position in the second group and then every 15 minutes until the end of the surgery. After surgery, the incidence of abdominal and shoulder pain with VAS, nausea and vomiting in recovery room, 6, 12 and 24 hours later are evaluated. The onset time of pain and analgesic drug (methadone) are evaluated in the first 24 hours.