]>
IRCT201207109472N4 IRCT 2014-03-19 Vice-chancellor for Research, Tehran University of Medical Sciences, Vice chancellor for Research, I The effect of Ginger powder consumption on inflammation and Immunity in Rheumatoid arthritis disease The effect of Ginger consumption on the some immunity and inflammatory mediators in adult with active Rheumatoid arthritis referingto Shariaty Hospital 2014-03-11 anticipated 35 Complete https://irct.ir/trial/10051 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. 1 adult active Rheumatoid arthritis. Intervention 1: Intervention Group: Patients that refer to hospital shariatti have interval criteria and will receive Ginger voluntarily. Patients in case group will receive 1500 mg of powdered Ginger daily (by two 750 mg capsules) for 3 months ne 750 mg capsule before lunch and one before dinner for 3 months. Intervention 2: Control groups: Patients that refer to hospital shariatti have interval criteria and will receive starch or flour voluntarily. Patients in Control group will receive 1500 mg of wheat flour daily (by two 750 mg capsules) one 750 mg capsule before lunch and one before dinner for 3 months.
public Naheed Aryaeian
School of public health, Iran University of Medical Sciences, Hammat Bld.
Tehran Iran (Islamic Republic of) +98 21 8670 4755 aryaeian@razi.tums.ac.ir Nutrition faculty, Iran University of Medical Sciences scientific Naheed Aryaeian
Department of nutrition, School of public of health, Iran University of Medical Sciences
Tehran Iran (Islamic Republic of) 1449614535 +98 21 8670 4755 n-aryaeian@tums.ac.ir Iran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: person with RA diseases as ACR criteria, having RA from 2 years ago; age between 18-69 years; not being pregnant or lactated; not smoking and drink alcohol; haven’t eaten multivitamin or antioxidants supplements from 3 month ago; don't eat lowering blood pressure; don't eat anti pregnancy drugs, exclusion criteria: Changes in diet or physical activity every day; taking less than 80% of supplements given to patients at baseline(the compliance lower than %80); consumption of contraceptives, multivitamins and antioxidant supplements; renal , hepatic , thyroid, parathyroid diseases, cancer, heart diseases 18 years 69 years Both M06.9 Rheumatoid arthritis, unspecified Treatment - Other Placebo Intervention Group: Patients that refer to hospital shariatti have interval criteria and will receive Ginger voluntarily. Patients in case group will receive 1500 mg of powdered Ginger daily (by two 750 mg capsules) for 3 months ne 750 mg capsule before lunch and one before dinner for 3 months. Control groups: Patients that refer to hospital shariatti have interval criteria and will receive starch or flour voluntarily. Patients in Control group will receive 1500 mg of wheat flour daily (by two 750 mg capsules) one 750 mg capsule before lunch and one before dinner for 3 months. HsCRP. Timepoint: Before and after intervention. Method of measurement: Elisa. IL17. Timepoint: Before and after intervention. Method of measurement: ELISA. TNFa. Timepoint: Before and after intervention. Method of measurement: ELISA. IL10. Timepoint: Before and after treatment. Method of measurement: ELISA. IL2. Timepoint: Before and after intervention. Method of measurement: ELISA. DAS28. Timepoint: Before and after study. Method of measurement: using ESR,CRP and number of joints with inflammation. IL4. Timepoint: Before and after treatment. Method of measurement: ELISA. ESR. Timepoint: Before and after the study. Method of measurement: Westergern method. BMI. Timepoint: Before and after intervention. Method of measurement: weight(kg)/height(m*2). Nsaids intake. Timepoint: Before and after intervention. Method of measurement: questionnaire. Vice-chancellor for Research, Tehran University of Medical Sciences, Vice chancellor for Research, I Approved 2014-02-04 Tehran university of medical sciences Tehran university of medical sciences,Research deputy Tehran Iran (Islamic Republic of)