IRCT201204199510N1 IRCT 2014-02-26 Tehran University of Medical Sciences Wheat oral desensitization in patient with wheat allergy Wheat Oral Immunotherapy Evaluation of efficacy and safety of wheat oral immunotherapy in patient with wheat allergy 2012-06-21 anticipated 15 Complete https://irct.ir/trial/10085 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Condition 1: wheat allergy. Condition 2: Desensitization. The anaphylactic patients take Loratadine and Montelukast, three days prior to admission to prevent the severe adverse reaction. On the first day of admission; we perform OFC again with premedication, so we determine the initial dose of rush OIT. In rush phase, patients take bread two time a day, and if they can take them without severe reactions, they are asked to take bread with 50% increase of the former dose. Maximum amount of bread is set at 52 g of bread. In outpatient method after the OFC, the patients are asked to ingest a small amount of wheat at home every day. The initial protein dose is about 1/4 of the threshold to elicit positive symptoms in OFC without premedication. Amount of wheat ingestion gradually buildup to 52 g of bread that contain 5.2g of wheat protein according to their symptoms. In both groups after completion of build-up phase, the patients are asked to ingest 52 g of bread containing 5.2 g wheat protein as a maintenance dose "daily" for 3 months. During this period the patients should continue the wheat-elimination diet. َََAt the end of maintenance phase we performed OFC with 52 g of bread (containing 5.2 g wheat protein). If the patients could pass the test, we regarded them as desensitized, and after that they could ingest wheat products without any restrictions. The patients who completed treatment had to eat at least 5.2 g wheat protein every day since we were not sure whether they have got tolerance or not. Moreover it is not difficult for most of people to eat 5.2 g wheat protein per day, because they usually have the same amount of wheat products in their daily diet..