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IRCT201302079608N1 IRCT 2013-09-10 Tehran University of Medical Sciences Vitamin D effects in asthma - Evaluation of vitamin D supplementation on airways function and inflammation in 10-50 years old asthmaics in rasool e akram hospital 2013-02-19 anticipated 120 Complete https://irct.ir/trial/10176 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: --. N/A Asthma. Intervention 1: Patient in the case group will receive appropriate Asthma controller according their Asthma stage which is inhaled oral corticosteroid with appropriate dose and extra than standard asthma treatment they will use vitamin D supplementation .they will inject 100000unit of Vit D intramuscular followed by 50000 unit Vit D orally weekly for 6 months. Intervention 2: Patients in the control group only receive asthma controller drug as oral inhaler corticosteroid according their asthma stage with appropriate dose without any supplementation.
public Morteza Fallahpour
Unit3, Nomber27, Siami Avenue, SattarKhan Street
Tehran Iran (Islamic Republic of) - +98 21 6692 8014 fallahpour.morteza@gmail.com Tehran University of Medical Sciences scientific Saba Arshi
unit 11, 7 street, Sarv Square, Saadat Abad
Tehran Iran (Islamic Republic of) = +98 21 2255 4933 sabaarshi@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Age 10-50; Asthma diagnosis according to spirometry and GINA guidlines; Ruled out of COPD and any chronic lung diseases; No asthma attack in previous 3 months; No pregnancy; No malignancy; sarcoidosis; renal or intestinal diseases or hyper sensitivity to vitamin D; No use of systemic corticoesteroid or anti convulsant Exclusion criteria No inclusion criteria; No consent to this program 10 years 50 years Both j45 Asthma Treatment - Drugs Treatment - Drugs Patient in the case group will receive appropriate Asthma controller according their Asthma stage which is inhaled oral corticosteroid with appropriate dose and extra than standard asthma treatment they will use vitamin D supplementation .they will inject 100000unit of Vit D intramuscular followed by 50000 unit Vit D orally weekly for 6 months. Patients in the control group only receive asthma controller drug as oral inhaler corticosteroid according their asthma stage with appropriate dose without any supplementation. Airway function. Timepoint: Before and after 8week, 16 week and after 6month. Method of measurement: Oscilometry. Airway function. Timepoint: Before and after 8week, 16 week and after 6month. Method of measurement: Spirometry. Serum vitamin D level. Timepoint: Before and after 8week, 16 week and after 6month. Method of measurement: eliza (serum). Serume Ig E level. Timepoint: before and after study. Method of measurement: ELIZA. Tehran University of Medical Sciences Approved 2012-10-12 Tehran University of Medical Sciences Corner of Ghods street, Keshavarz boulvard Tehran Iran (Islamic Republic of)