]>
IRCT201205079662N2 IRCT 2012-06-10 Isfahan University of Medical Sciences Effects of natural and commercial orange juice consumption in inflammatory factors ( hs-CRP; ICAM; VCAM; IL-6; E-Selectin )and endothelial function evaluation (FMD ) in healthy volunteers Effects of natural and commercial orange juice consumption in blood pressure and inflammatory factors in healthy volunteers 2012-02-20 anticipated 30 Complete https://irct.ir/trial/10223 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Crossover, Purpose: Prevention. N/A Condition 1: Blood pressure. Condition 2: flow-mediated dilatation (FMD). Intervention 1: 500 ml of fresh orange juice consumption in group 1 for 4wk. Intervention 2: 500 ml of Commercial orange juice consumption in group 1, for 4wk. http://www.ncbi.nlm.nih.gov/pubmed/23696766 Abstract <br /> BACKGROUND: Citrus sinensis juice (CSJ) is a rich source of dietary flavonoids which reduce <br /> the risk of adverse cardiovascular events. This study aimed to examine the effects of four-week <br /> intake of natural and commercial orange (Citrus sinensis) juice on blood pressure in healthy <br /> volunteers. <br /> METHODS: In this single-blind randomized crossover study, 22 healthy subjects (age: 18-59 <br /> years old) were included and randomly divided into two groups of 11. Group A consumed <br /> commercial CSJ during the first four-week period. After a two-week washout period, they <br /> consumed natural CSJ for another four weeks. The procedure was reversed in group B. The <br /> participants were asked to drink 500 ml/day of either natural or commercial CSJ twice a day <br /> with breakfast and dinner. The effects of orange juice on blood pressure were evaluated. <br /> RESULTS: After drinking commercial CSJ, diastolic and systolic blood pressure were <br /> significantly decreased (5.13%; P = 0.03 and -5.91%; P = 0.003, respectively). However, <br /> consumption of natural CSJ did not have significant effects on either diastolic or systolic blood <br /> pressure. <br /> CONCLUSION: Commercial CSJ significantly decreased blood pressure. Higher flavonoid, <br /> pectin, and essential oils content of concentrated products compared to natural juice might have <br /> been responsible for this finding. Nevertheless, further studies to focus on dose-response effects <br /> are recommended. <br /> Keywords:Citrus sinensis Juice, Hypertension, Blood Pressure
public
scientific Sedigheh Asgary
Khorram Street, Jomhoori Square
Isfahan Iran (Islamic Republic of) +98 31133595959 sasgary@yahoo.com Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of M Iran (Islamic Republic of) Inclusion criteria: Healthy individuals 19-59 years. Exclusion criteria: Individuals with a history of diseases; diabetes; cardiovascular disease; liver and kidney as well as those with thyroid disease; pregnant and breastfeeding; individuals with dyslipidemia, metabolic and endocrine diseases and those with a vegetarian diet. 19 years 59 years Both I10-I15 I70-I79 Hypertensive diseases Diseases of arteries, arterioles and capillaries Other Other 500 ml of fresh orange juice consumption in group 1 for 4wk 500 ml of Commercial orange juice consumption in group 1, for 4wk. Positive changes in inflammatory markers. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA kit. Positive changes in endothelial function. Timepoint: Baseline and after 4 weeks. Method of measurement: Doppler ultrasonography. Decrease in blood pressure. Timepoint: Baseline and after 4 weeks. Method of measurement: Sphygmomanometer. Positive changes in lipid profiles. Timepoint: Baseline and after 4 weeks. Method of measurement: kit. Cholesterol Level. Timepoint: Before and after 4 weeks. Method of measurement: KIT. HDL Level. Timepoint: Before and after 4 weeks. Method of measurement: KIT. LDL level. Timepoint: Before and after 4 weeks. Method of measurement: KIT. Isfahan University of Medical Sciences Approved 2010-09-23 Isfahan University of Medical Sciences Hezar jirib st. Isfahan Iran (Islamic Republic of)