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IRCT201304079936N4 IRCT 2013-07-02 Shiraz University of Medical Sciences Randomized Double-blind Placebo Controlled Trial of Topical Platelet Lysate hydrogel in patients with anal fissure referee to colorectal research center of shiraz medical university of medical sciences. Randomized Double-blind Controlled Trial of Topical Platelet Lysate hydrogel in patients wit Randomized Double-blind Placebo Controlled Trial of Topical Platelet Lysate hydrogel in patients with anal fissure referee to colorectal research center of shiraz medical university of medical sciences. 2013-02-03 anticipated 82 Complete https://irct.ir/trial/10452 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: There is significant differentiation between sphincter pressure in male and female therefore, management response in male and female will be are different as little then this study will be perform in female participantant . N/A Fissure. Intervention 1: The rectul drug will be used once daily in control group. Intervention 2: the platelet gel will be used once daily transrectaly in Intervention group.
public Akram Jamshidzadeh,pharm.D PhD
Shiraz University of pharmacy- Akbar Abad
Shiraz Iran (Islamic Republic of) Iran +98 71 1230 6972 colorectal2@sums.ac.ir Shiraz University of pharmacy, Shiraz University of Medical Sciences scientific Leila ghahramani, Assistant Professor of surgery
Colorectal Research Center, Shiraz University of Medical Sciences
Shiraz Iran (Islamic Republic of) +98 71 1230 6972 leila_ghahramani@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria:1 )Patient with acute and chronic anal fissure. 2) Patient without previous history of peri-anal fistula. 3) Patient without previous history of peri-anal abscess. 4) Patient without previous history of IBD, radiation, STD, TB Chemotherapy. 5) Patient without previous history of hemorrhoidectomy or peri-anal procedure. 6) Patient without previous history of migraine. 7) Patient without previous history of no pregnant. 8) Patient without previous history of anterior or posterior midline fistula. 9) Patient without previous history of IHD. 18 years 65 years Female K60 Fissure and fistula of anal and rectal regions Treatment - Drugs Treatment - Drugs The rectul drug will be used once daily in control group. the platelet gel will be used once daily transrectaly in Intervention group Treatment of fissure. Timepoint: Two weeks after initial treatment. Method of measurement: Exam by colorectal surgeon and complete the form. Shiraz University of Medical Sciences Approved 2012-10-08 Shiraz University of Medical Sciences Shiraz University of Medical Sciences Shiraz Iran (Islamic Republic of)