IRCT2012121810210N2 IRCT 2013-01-18 Shiraz university of medical sciences Effects of letrozole versus clomiphene citrate in combination with ghonadotropins on IUI cycle in infertile couples Effects of letrozole versus clomiphene citrate in combination with recombinant follicle-stimulating-hormone in induction ovulation on intrauterine insemination outcome 2009-10-01 anticipated 144 Complete https://irct.ir/trial/10681 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Infertility and treatment methods. Intervention 1: Group A patients received 5 mg/day letrozole at days 5-9 menstrual cycle before IUI (n=72). All patients received 150 IU rFSH (Gonal-f, Serono, Hellas, Puregon, Greece) from day 8 until day of hCG administration.10000 IU of hCG (Choriomon, IBSA, Switzerland) was injected when there were one or two mature follicles with diameter of more than 18 mm. A single IUI was performed 36-40 hours after hCG administration. Intervention 2: Group B received 100-mg per day clomiphene citrate (Razak Drug Laboratory, Tehran, Iran) for 5 days in at days 5-9 menstrual cycle and 150 IU rFSH from day 8 until day of hCG administration.10000 IU of hCG was injected when there were one or two mature follicles with diameter of more than 18 mm. A single IUI was performed 36-40 hours after hCG administration.