]>
IRCT2013081410297N2 IRCT 2013-11-23 Vice chancellor for research, Isfahan University of medical sciences Effect of Pentoxifylline treatment on quality of life and change in arm circumference compared to placebo in patients with cancer cachexia: A double-blind, randomized, placebo-controlled trial Effect of Pentoxifylline treatment on quality of life and change in arm circumference compared to placebo in patients with cancer cachexia: A double-blind, randomized, placebo-controlled trial 2011-10-15 anticipated 70 Complete https://irct.ir/trial/10753 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Malignant neoplasm. Intervention 1: Intervention group will receive Pentoxifylline (400 mg) three times a day. Intervention 2: Control group will receive exactly similar placebo capsules regarding shape, size and taste.
public Valiollah Mehrzad
Department of Clinical Oncology, School of Medicine, Isfahan University of Medical Sciences, Hezar Jarib Ave., Azadi Sq.
Isfahan Iran (Islamic Republic of) +98 31 1668 5555 valimehrzad@yahoo.com Isfahan University of Medical Sciences scientific Valiollah Mehrzad
Department of Clinical Oncology, School of Medicine, Isfahan University of Medical Sciences, Hezar Jarib Ave., Azadi Sq.
Isfahan Iran (Islamic Republic of) +98 31 1668 5555 valimehrzad@yahoo.com Isfahan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria are: 1. Histologic or cytologic proof evidencing cancers, 2. Incurable malignancy with a life expectancy≥4 months, 3. Weight loss perceived by the patient as a problem, 4. Patient should be alert and mentally competent. Exclusion criteria are: 1. Affliction with edema or ascites, 2. Adrenal corticosteroids treatment (except for dexamethasone during chemotherapy) androgens, progestational agents, or other appetite stimulants within the previous month, 3. Brain metastases, 4. Pregnancy or lactation, 5. Mechanical obstruction of the alimentary tract, 6. Malabsorption, or intractable vomiting, 7. Poorly controlled hypertension or congestive heart failure. 18 years 90 years Both C80.9 Malignant neoplasm, without specification of site Treatment - Drugs Placebo Intervention group will receive Pentoxifylline (400 mg) three times a day. Control group will receive exactly similar placebo capsules regarding shape, size and taste. Arm circumference. Timepoint: before and two months after intervention. Method of measurement: Meter calibrated. Quality of life. Timepoint: before and two months after intervention. Method of measurement: SF-36 standard questionnaire. Side effects. Timepoint: during treatment. Method of measurement: clinical observation (nausea / vomiting / tachycardia). Vice chancellor for research, Isfahan University of medical sciences Approved 2011-08-17 Ethics Committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar Jarib Ave., Azadi Sq Isfahan Iran (Islamic Republic of)