]>
IRCT2015020110326N2 IRCT 2015-09-25 Vice Chancellor for Research & Technology, Hormozgan University of Medical Sciences Efficacy of Captophyte compound in comparison with Captopril alone on blood pressure in patients with essential hypertension Efficacy of Captophyte compound in comparison with Captopril alone on blood pressure in patients with essential hypertension 2015-10-01 anticipated 50 Complete https://irct.ir/trial/10823 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Random number generator table. 2 Essential Hypertesion. Intervention 1: Intervention 1: Captophyte compound divided in two equal 2g doses of red algae and combined with captopril 25 mg tablets in a capsule (Captophyte capsule) three times daily for 28 days. Intervention 2: Control group: 25 mg captopril combined with placebo (from DANA pharmaceuticals) is used for 28 days.
public Dr Seyedeh Tasnim Eghbal Eftekhaari
Molecular Medicine Research Center, Shahid Mohammdi Hospital, Jomhouri Blvd
Bandar-e Abbas Iran (Islamic Republic of) 7919915519 +98 76 3333 7192 teftekhari@hums.ac.ir; tasnim.eftekhaari@gmail.com Hormozgan University of Medical Sciences scientific Dr Abdolazim Nejatizadeh
Department of Research & Technology, Shahid Mohammdi Hospital, Jomhouri Blvd
Bandar-e Abbas Iran (Islamic Republic of) 7919915519 +98 76 3333 7192 anejatizadeh@hums.ac.ir; azimnejate@yahoo.com Hormozgan University of Medical Sciences, Iran (Islamic Republic of) Inclusion criteria: essential hypertension; age of 20 - 55 years and no response to diet and exercise in prehypertension state. Exclusion criteria: one or more of the following: Creatinine levels > 1.5 mg/dl; elevated liver enzymes; intake of any of the anti-hypertensive medications (nitrates, beta blockers, anhydrase carbonic inhibitors, calcium channel blockers, diuretics and angiotensin receptor blocker) due any other underlying medical causes; concurrent intake of any medications having hepatic metabolism (with super enzymes of cytochrome p450 including CYP2D6 (i.e. imipramine, fluoxetine, promethazine, celcoxib, hydroxyzine, citalopram, dextrometorphan, codeine, ondansetron, tamoxifen, tarmadol ). CYP3A4 (clarythromycin, erythromycin, cimetidine, carbamazepine, phenytoin, phenobarbital, rifampin, corticosteroids, atorvastatin, benzodiazepines, and haloperidol) which metabolize most of BB, CCB, ACEI, ARB; medication with warfarin; other cardiovascular complications such as angina pectoris, IHD, hypertensive crisis, or cerebrovascular accidents such as TIA, or stroke which require CCB, BB, ACE; GI disturbances; allergic reactions; immunologic reactions; unwillingness to participate in the study; death of the patient. 20 years 55 years Both I10 Essential (primary) hypertension Treatment - Drugs Treatment - Drugs Intervention 1: Captophyte compound divided in two equal 2g doses of red algae and combined with captopril 25 mg tablets in a capsule (Captophyte capsule) three times daily for 28 days. Control group: 25 mg captopril combined with placebo (from DANA pharmaceuticals) is used for 28 days Blood pressure. Timepoint: Every week for 28 days. Method of measurement: Measuring blood pressure with mercury sphygmomannometer. Vice Chancellor for Research & Technology, Hormozgan University of Medical Sciences Approved 2015-08-25 Hormozgan University Ethics Committee Shahid Mohammadi hospital, Department of research & Technology, Ethics Committee Bandar-e Abbas Iran (Islamic Republic of)