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IRCT138711131630N1 IRCT 2013-02-23 Shiraz University of Medical Sciences Effect of atorvastatin on cardiac arrhythmias after open heart surgery Effect of atorvastatin on the incidence of atrial fibrillation in patients undergoing coronary artery bypass graft surgery 2012-04-07 anticipated 150 Complete https://irct.ir/trial/1087 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 3 Atrial fibrillation. Intervention 1: Patients in case group will receive atorvastatin 20 mg, once daily 3 days before surgery, and 6 hours after extubation up to the day 5 after surgery. In the case of assisted respiration by ventilator, the drug will be administered through NG tube. All patients will receive beta blockers before surgery. During surgery, patient will be cooled to the 32 C, anesthesized with similar anesthetic agents and operated by an individual surgeon. All patients will be observed for the incidence of atrial fibrillation till discharge from hospital. Intervention 2: Patients in control group will receive placebo, once daily 3 days before surgery, and 6 hours after extubation up to the day 5 after surgery. In the case of assisted respiration by ventilator, the drug will be administered through NG tube. All patients will receive beta blockers before surgery. During surgery, patient will be cooled to the 32 C, anesthesized with similar anesthetic agents and operated by an individual surgeon. All patients will be observed for the incidence of atrial fibrillation till discharge from hospital.
public Hossein Mirkhani
School of Medicine, Zand Blvd.
Shiraz Iran (Islamic Republic of) +98 71 1230 7591 mirkhanh@sums.ac.ir Shiraz University of Medical Sciences scientific Hossein Mirkhani
School of Medicine, Zand Blvd.
Shiraz Iran (Islamic Republic of) +98 71 1230 7591 mirkhanh@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: Patients undergoing isolated coronary artery bypass graft surgery. Exclusion criteria: 1. History of atrial fibrillation; 2. Renal failure with plasma creatinine greater than 2 mg/dl; 3. Malignant or inflammatory diseases; 4. Routine use of atorvastatin; 5. Mixed cardiac operations including valve replacement; 6. Using antiarrhythmic drugs except beta-blockers; 7. Active hepatic-biliary diseases; 8. Increase in serum transaminases with undetermined cause; 9. Patients re-operated because of bleeding or other complications of surgery; 10. Glucocorticoids use. no limit no limit Both I48 Atrial fibrillation and flutter Prevention Placebo Patients in case group will receive atorvastatin 20 mg, once daily 3 days before surgery, and 6 hours after extubation up to the day 5 after surgery. In the case of assisted respiration by ventilator, the drug will be administered through NG tube. All patients will receive beta blockers before surgery. During surgery, patient will be cooled to the 32 C, anesthesized with similar anesthetic agents and operated by an individual surgeon. All patients will be observed for the incidence of atrial fibrillation till discharge from hospital. Patients in control group will receive placebo, once daily 3 days before surgery, and 6 hours after extubation up to the day 5 after surgery. In the case of assisted respiration by ventilator, the drug will be administered through NG tube. All patients will receive beta blockers before surgery. During surgery, patient will be cooled to the 32 C, anesthesized with similar anesthetic agents and operated by an individual surgeon. All patients will be observed for the incidence of atrial fibrillation till discharge from hospital. Atrial fibrillation after Coronary Artery Bypass Graft surgery. Timepoint: During 5 days after operation. Method of measurement: ECG monitoring. Shiraz University of Medical Sciences Approved 2011-10-06 Ethics committee of Shiraz University of Medical Sciences Zand Blvd. central building of Shiraz University of Medical Sciences Shiraz Iran (Islamic Republic of)