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IRCT2012081110559N1 IRCT 2013-03-03 Vice chancellor for research, Tehran University of Medical Sciences Effect of "Cydonia Oblonga" fruit on nausea and vomiting in pregnancy Comparison of "Cydonia Oblonga" fruit product with B6 on nausea and vomiting in pregnancy 2013-02-19 anticipated 90 Complete https://irct.ir/trial/11047 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization will conducted by the table of random number. 2 Nausea and vomiting induced by pregnancy. Intervention 1: Intervention: syrup of Quince fruit, 1 table spoon three times a day before meals for one week Control: Vitamin B-6 20 mg tablet three times daily before meals for one week. Intervention 2: control: Vitamin B-6 20 mg tablet three times daily before meals for one week.
public Efat Jafari Dehkordi
Faculty of Traditional Medicine, Behesht St., Vahdat Eslami Ave., Tehran, IRAN
Tehran Iran (Islamic Republic of) +98 21 5569 3520 e-jafarid@razi.tums.ac.ir Faculty of Traditional Medicine, Tehran University of Medical Sciences scientific Efat Jafari Dehkordi
Faculty of Traditional Medicine, Behesht St., Vahdat Eslami Ave., Tehran, IRAN
Tehran Iran (Islamic Republic of) +98 21 5569 3520 e-jafarid@razi.tums.ac.ir Faculty of Traditional Medicine, Tehran University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: age 18-40 years, gestational age 6-14 weeks, singleton pregnancy with live fetus based on ultrasound, mild to moderate nausea and vomiting of pregnancy (13 > score of PUQE 24 Questionnaire ≥ 6) Exclusion criteria: severe nausea and vomiting during pregnancy that may require fluid therapy and hospitalization, nausea and vomiting of pregnancy by secondary causes: peptic ulcer, hepatitis, pyelonephritis, pancreatitis, cholecystitis, appendicitis, gastroenteritis, UTI, CNS disorders, gasteroesophageal reflux disease, hyperthyroidism, multiple pregnancy, ectopic pregnancy, mole, presence of pregnancy complications such as bleeding, threatened abortion, history of chronic disease, history of drug addiction, alcoholism and smoking, history of drug allergy, and at least 48 hours before presentation anti- nausea medication (B6, Metoclopramide, etc.) are not used 18 years 40 years Female O21.9 Vomiting of pregnancy, unspecified Treatment - Drugs Treatment - Drugs Intervention: syrup of Quince fruit, 1 table spoon three times a day before meals for one week Control: Vitamin B-6 20 mg tablet three times daily before meals for one week control: Vitamin B-6 20 mg tablet three times daily before meals for one week Nausea. Timepoint: Before, one week and two weeks after intervention. Method of measurement: PUQE 24 hours Questionnaire and VAS (Visual Analogue Scale). Vomiting. Timepoint: Before, one week and two weeks after intervention. Method of measurement: PUQE 24 hours Questionnaire and VAS (Visual Analogue Scale). Retching. Timepoint: Before, one week and two weeks after intervention. Method of measurement: PUQE 24 hours questionnaire and VAS (Visual Analogue Scale). Research Institute for Islamic and Complementary Medicine, (Tehran University of Medical Sciences) Vice chancellor for research, Tehran University of Medical Sciences Research Institute for Islamic and Complementary Medicine, (Tehran University of Medical Sciences) Approved 2012-10-09 Ethics committee of the Research Institute for Islamic and Complementary Medicine, (Tehran Universit No: 9, Pirnia Alley, Lalehzar St., Jomhury Ave., Tehran, Iran Tehran Tehran Iran, Islamic Republic Of Tehran Iran (Islamic Republic of)