IRCT2012090410743N1 IRCT 2012-11-30 Vice-chancellor for research -Jahrom University of Medical Science Meperidine effect on intraoperative and postoperative shivering of caesarean section under spinal anesthesia Study of low dose intrathecal meperidine on intra- and post-operative shivering in caesarean section under spinal anesthesia:a prospective double-blind, randomized Clinical Trial 2012-10-06 anticipated 70 Complete https://irct.ir/trial/11158 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. N/A Spinal anesthesia. Intervention 1: 10 mg bupivacaine 0.5% and 10 mg meperidine by Spinal Anesthesia (group BP, n=35). Intervention 2: placebo (10 mg bupivacaine 0.5% and normal saline, (group B, n=35) by spinal Anesthesia.

public Hasan Zabetian

Jahrom University of Medical Sciences

Jahrom Iran (Islamic Republic of) +98 79 1334 0405 h_zabetian@yahoo.com Jahrom University of Medical Sciences scientific Mohammad Yasin Karami

Motahhari Ave, Student Research Committee, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, I.R.Iran

Jahrom Iran (Islamic Republic of) +98 79 1334 0405 yasinkarami@gmail.com Jahrom university of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: parturients [ASA physical status I or II]; age between 18 - 40 years old. exclusion criteria: sever preeclampsia; contraindication to local anesthesia and caesarean section surgery; diabetes; preoperative body temperature>38ᴏC (fever); allergy to the study medications (meperidine and bupivacaine); ASA III; drug addiction; height <152 cm; Raynaud’s syndrome; hypo or hyperthyroidism; BMI less than 19; BMI high than 25; 18 years 40 years Female O29.5 Other complications of spinal and epidural anaesthesia during pregnancy Prevention Placebo 10 mg bupivacaine 0.5% and 10 mg meperidine by Spinal Anesthesia (group BP, n=35) placebo (10 mg bupivacaine 0.5% and normal saline, (group B, n=35) by spinal Anesthesia. Shivering incidence. Timepoint: Spinal Anesthesia to recovery room. Method of measurement: Crossley and Mahajan Scale. Shivering Intensity. Timepoint: Spinal Anesthesia to recovery room. Method of measurement: Crossley and Mahajan Scale. Systolic Blood Pressure. Timepoint: Start to end Of Surgery. Method of measurement: mmHg. Central Core Tempreture. Timepoint: Start to end Of Surgery. Method of measurement: Celcious. BMI. Timepoint: Start of Study. Method of measurement: KG/M2. APGAR Score. Timepoint: Post birth. Method of measurement: APGAR Scale. Highest block Segment. Timepoint: each 5 minutes during first 30 minutes of post Spinal anesthesia. Method of measurement: Pinprick. Diastolic Blood pressure. Timepoint: Start to end Of Surgery. Method of measurement: mmHg. Basic heart rate. Timepoint: Start to end Of Surgery. Method of measurement: beats per min. Basic peripheral oxygen saturation. Timepoint: Start to end Of Surgery. Method of measurement: Percent. Surgery Duration. Timepoint: Start to end Of Surgery. Method of measurement: Minute. Time to reach highest block. Timepoint: Anesthesia onset. Method of measurement: minute. Sensory Level. Timepoint: Anesthesia onset. Method of measurement: Range. Nausea And Vomitting. Timepoint: Post operation. Method of measurement: Observation. Pruritus. Timepoint: Post operation. Method of measurement: Patient feel. Respiratory distress. Timepoint: During and Post operation. Method of measurement: Observation. Hypotension. Timepoint: During and Post operation. Method of measurement: mmHg. Bradycardia. Timepoint: During and Post operation. Method of measurement: Beat per minute. Tachycardia. Timepoint: During and Post operation. Method of measurement: Beat per minute. Vice-chancellor for research -Jahrom University of Medical Science Approved 2012-08-04 Jahrom University of Medical Sciences ethics Committee Ostad Motahhari Street, site of Paradise jahrom Iran (Islamic Republic of)