<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT2012090510747N1</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2012-11-23</date_registration>
      <primary_sponsor>Vice chancellor for research ,Dental Faculty of  Islamic Azad University of Tehran</primary_sponsor>
      <public_title>Comparison of  the effect of ordinary yogurt drink with probiotic yogurt drink on the level of salivary Streptococcus Mutans</public_title>
      <acronym></acronym>
      <scientific_title>Comparison of  the effect of ordinary yogurt drink with probiotic yogurt drink on the level of salivary Streptococcus Mutans of dental student of Islamic Azad University in 1390</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2011-11-06</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>30</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/11165</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Prevention.</study_design>
      <phase>2-3</phase>
      <hc_freetext>Condition 1: level of salivary streptococcus mutans. Condition 2: Enamel Caries.</hc_freetext>
      <i_freetext>Intervention 1: Intervention Study Groups: a group that received probiotic yogurt drink. The considered yogurt drink was a production of Pegah Company and contains Lactobacilus Acidophilus and Bifidobacterium Bifidum.&#13;
&#13;
 &#13;
&#13;
Each participant has been asked to take 200 cc amount of probiotic yogurt drink 10 minutes after dinner meal and not to brush their teeth for an hour after that. Intervention 2: Control group 1: a group that received regular yogurt drink.The considered yogurt drink was a production of Pegah Company.&#13;
&#13;
 &#13;
&#13;
Each participant have been asked to take 200 cc amount of regular yogurt  drink 10 minutes after dinner meal and not to brush their teeth for an hour after that. Intervention 3: Control group2:  a group that did not use any yogurt drinks.&#13;
&#13;
  The control group has been asked not to use any yogurt drink or probiotic products in three weeks through the study.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan></results_IPD_plan>
      <results_IPD_description></results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Mohamadreza Mohamadi</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>NO.4 , 10th Neyestan street , Pasdaran Ave. ,Tehran ,Iran</address>
        <city>Tehran</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip></zip>
        <telephone>+98 26 3254 4780</telephone>
        <email>Mreza_Mohamadi88@yahoo.com</email>
        <affiliation>Dental Faculty of  Islamic Azad University of Tehran</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Mohamadreza Mohamadi</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>NO.4 , 10th Neyestan street , Pasdaran Ave. ,Tehran ,Iran</address>
        <city>Tehran</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip></zip>
        <telephone>+98 26 3254 4780</telephone>
        <email>Mreza_Mohamadi88@yahoo.com</email>
        <affiliation>Dental Faculty of  Islamic Azad University of Tehran</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Exclusion criteria: Topical Fluoride Therapy, any use of fluoride or antibacterial mouthwashes  in the past three weeks before the study;  Any antibiotic therapy two weeks prior to the study; Any use of  Xylitol-contained  products during the study; Any yogurt drink or probiotic products consumption during  a week before the study .&#13;
&#13;
 &#13;
&#13;
Inclusion criteria: A dental student</inclusion_criteria>
      <agemin>18 years</agemin>
      <agemax>40 years</agemax>
      <gender>Both</gender>
      <exclusion_criteria></exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code>__________</hc_code>
      <hc_code>K02.0</hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword>___________</hc_keyword>
      <hc_keyword>White spot lesions , initial caries</hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Prevention</i_code>
      <i_code>Prevention</i_code>
      <i_code>Prevention</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>Intervention Study Groups: a group that received probiotic yogurt drink. The considered yogurt drink was a production of Pegah Company and contains Lactobacilus Acidophilus and Bifidobacterium Bifidum.&#13;
&#13;
 &#13;
&#13;
Each participant has been asked to take 200 cc amount of probiotic yogurt drink 10 minutes after dinner meal and not to brush their teeth for an hour after that.</i_keyword>
      <i_keyword>Control group 1: a group that received regular yogurt drink.The considered yogurt drink was a production of Pegah Company.&#13;
&#13;
 &#13;
&#13;
Each participant have been asked to take 200 cc amount of regular yogurt  drink 10 minutes after dinner meal and not to brush their teeth for an hour after that.</i_keyword>
      <i_keyword>Control group2:  a group that did not use any yogurt drinks.&#13;
&#13;
  The control group has been asked not to use any yogurt drink or probiotic products in three weeks through the study.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Level of salivary streptococcus mutans. Timepoint: one day before any intervention  ,one day  after any intervention. Method of measurement: culture in mittis salivarius agar.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome></sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Vice chancellor for research ,Dental Faculty of  Islamic Azad University of Tehran</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2011-11-02</approval_date>
        <contact_name>Ethics Committee of the Dental Faculty of  Islamic Azad University of Tehran</contact_name>
        <contact_address>NO.4 , 10th Neyestan street , Pasdaran Ave. ,Tehran ,Iran Tehran  Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
