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IRCT20120907010765N14 IRCT 2019-03-13 Vice Chancellor of Tabriz University of Medical Sciences Perioperative Hemodynamic Responses and Analgesic requirements Post Gynecologic Laparoscopic Surgeries Comparison of Premedication with Oral Clonidine and Infusion of Dexmedetomidin on Perioperative Hemodynamic Responses and Analgesic requirements Post Gynecologic Laparoscopic Surgeries 2016-10-22 anticipated 60 Complete https://irct.ir/trial/11181 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: By Randomly Permuted Blocks method and using online randomization software, Patients were randomly assigned to one of the intervention groups, Blinding description: Blinding of the intervention will be applied in a double-blinding procedure, such that the patients were unaware from the administered medicine and the anesthesiologists who is responsible for the induction of anesthesia will be administered the study medications to the patients ,then the outcome assessor (the one who were blinded about the administered drugs)will be evaluate patients pain and sedation score and hemodynamic status. 1-2 Laparoscopic surgery. Intervention 1: Group one will be received infusion of 1 µg/kg Dexmedtomidine in 20 ml normal saline over 10 minute immediately before operation. Intervention 2: Group two will be received an oral tablet of 0.2 mg Clonidine 90 minute before operation. Yes - There is a plan to make this available What will be shared: Shared data/documents in this study include patients characteristics(demographic data)and those information related to the primary outcome(s). All patients private data like name.surname,file number will not be shared and completely remained closed. When: starting 1 year after publication. To whom: people working in academic institutions can be apply to receive it. Conditions: criteria for using the information/documents including remaining them completely private and closed .They can be used only for comparison with other data and studies. Where to obtain: the applicants can get the documents via corresponding author email address and contact with him/her. How to obtain: After email contact with corresponding author and Set the schedule for time(at most 2 weeks)data will be sent as a computer file to the email address of the applicant(s). Comments:
public Farnaz Moslemi Tabrizi
Alzahra Hospital, South Artesh Ave
Tabriz Iran (Islamic Republic of) 5157611134 +98 41 3553 9161 moslemifa@gmail.com Vice Chancellor of Tabriz University of Medical Sciences scientific Farnaz Moslemi Tabrizi
Al-Zahra Hospital, South Artesh Street
Tabriz Iran (Islamic Republic of) 5157611134 +98 41 3553 9161 moslemifa@gmail.com Vice Chancellor of Tabriz University of Medical Scienses Iran (Islamic Republic of) patients will be schedule to gynecologic laparoscopy patients who accept for taking part in the study patients aged 20-40 patients with ASA class I or II 20 years 40 years Female patients with ASA class III or higher cardiovascular disease neurological disease renal or hepatic disease diabetics addicts Treatment - Drugs Treatment - Drugs Group one will be received infusion of 1 µg/kg Dexmedtomidine in 20 ml normal saline over 10 minute immediately before operation Group two will be received an oral tablet of 0.2 mg Clonidine 90 minute before operation. Severity of Postoperative Pain. Timepoint: evaluation of the severity of postoperative pain immediately after operation( approximately 1-2 hours after drug administration related to the operation time) in recovery ,then every 30 minutes until patients transfer to the ward. Method of measurement: Visual analog scale. Intra and Postoperative Blood pressure. Timepoint: 15 minutes after drug administration ,then every 15 minutes until patients transfer from recovery to the ward. Method of measurement: Non invasive monitoring of blood pressure with blood pressure monitor. Vice Chancellor of Tabriz University of Medical Sciences Approved 2016-07-04 Ethic committee of Tabriz University of Medical Sciences Tabriz University of Medical Scienses,Golgasht Ave,Tabriz,Iran Tabriz East Azarbaijan Iran (Islamic Republic of)