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IRCT2013031710841N4 IRCT 2013-04-22 Hamadan University Of Medical Science ,Vice chancellor for research Ketamin on reducing postoperative pain in cesarean section The effect of subcutaneous ketamine infiltration on postoperative pain in elective cesarean section under spinal anesthesia. 2013-03-21 anticipated 60 Complete https://irct.ir/trial/11266 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 2 cesarean postoperative pain. Intervention 1: After closure perituine in K group 0.5mg/kg(0.05ml/kg) ketamin subcutaneously is infiltrated and patient is transferd to recovery room. Intervention 2: After closure perituine in P group (0.05ml/kg) normal salin subcutaneously is infiltrated and patient is transfered to recovery room.
public Nahid Manouchehrian
Fatemieh Hospital,Pasdaran Street
Hamadan Iran (Islamic Republic of) 65177-8-9971 +98 81 1827 7012 fatemieh@umsha.ac.ir Hamadan University of Medical Science scientific Nahid Manouchehrian
Fatemieh Hospital,Pasdaran Street
Hamadan Iran (Islamic Republic of) 65177-8-9971 +98 81 1827 7012 manouchehrian@umsha.ac.irnmanuchehrian@yahoo.com Hamadan University Of Medical Science Iran (Islamic Republic of) Inclusion criteria: age between15-45 years old;ASA class 1&2; parturition candidate for cesarean section under spinal anesthesia. Exclusion criteria: history of hypertension; hyperthyroidism; convulsion; symptoms of increasing ICP ; psychiatric disorders; ischemic heart disease; valvular heart disease; allergy to Ketamin; liver & renal failure; alcohol or drugs abuse; spinal anesthesia contraindications(patients refuse, coagulation disorders, local infections, neurologic disorders, sever anemia,...) ; spinal failure & general anesthesia for surgery. 15 years 45 years Female 089.9 Complication of anaesthesia during the puerperium, unspecified Prevention Treatment - Drugs After closure perituine in K group 0.5mg/kg(0.05ml/kg) ketamin subcutaneously is infiltrated and patient is transferd to recovery room. After closure perituine in P group (0.05ml/kg) normal salin subcutaneously is infiltrated and patient is transfered to recovery room. Diastolic Blood Pressure. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring. Pain score. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: 10 centimeter ruller. Systolic Blood Pressure. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring. Heart rate. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring. Respiratory rate. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Observation & Examination. Blood oxygenation. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring. Analgesic requirement in 24 hours. Timepoint: During 24 hours. Method of measurement: Observation & calculation. Nausea. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation. Hallosination. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation &Examination. Nistagmus. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation &Examination. Sedation Level. Timepoint: pPreadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Ramsay Scale. Vomiting. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation. Hamadan University Of Medical Science ,Vice chancellor for research Approved 2012-11-22 Hamadan University Of Medical Sciences Hamadan University Of Medical Sciences,Medical School,Fahmide Street Hamadan Iran (Islamic Republic of)