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IRCT2014110210900N4 IRCT 2016-04-05 Vice chancellor for research, Kerman University of Medical Sciences analgesic effects of a drug in thoracic surgeries A randomized clinical trial on the effects of oral Pregabalin compared with placebo in acute postoperative pain in patients who undergo Thoracotomy 2014-01-19 anticipated 60 Complete https://irct.ir/trial/11310 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Acute pain. Intervention 1: In intervention group, 300 mg pregabalin is administered orally as an analgesic, 2 hours before surgery. Intervention 2: In control group placebo (a capsule similar to the drug without any effective substance) is administered.
public Hosein Sattari
Afzalipoor Hospital, Zendan Square
Kerman Iran (Islamic Republic of) +98 34 3223 5011 hosattari@gmail.com Kerman University of Medical Sciences scientific Hamid Jalalifard
Afzalipoor Hospital, Zendan Square
Kerman Iran (Islamic Republic of) 00 javakrd34@gmail.com Kerman University of Medical Sciences Iran (Islamic Republic of) Inclusion Criteria: Patients, who are admitted for thoracic surgery, age 20 to 65 year. Exclusion criteria: pregnancy, history of allergy to pregabalin, history of treatment with pregabalin or gabapentin, history of chronic pain syndromes and painkiller consumption, addiction to alcohol or drugs, allergy to pethidine, psychiatric drug consumption, surgery lasting more than 4 hours, uncontrolled blood pressure, history of convulsion and the patients who had preoperative pain based on the visual analogue scale (VAS) had preoperative pain. 20 years 65 years Both R52.0 Acute pain Treatment - Drugs Treatment - Drugs In intervention group, 300 mg pregabalin is administered orally as an analgesic, 2 hours before surgery In control group placebo (a capsule similar to the drug without any effective substance) is administered. Pain. Timepoint: At the end of operation and transferring to recovery room, the score of pain is measured every 15 minutes for an hour and after transporting to ward, every 4 hours for 24 hours. Method of measurement: VISUAL ANALOGUE SCALE. The dose of analgesic. Timepoint: during and after surgery. Method of measurement: recording the dose and frequency of administration. Vice chancellor for research, Kerman University of Medical Sciences Approved 2014-02-19 The ethics committee of Kerman University of Medical sciences Shafa Square Kerman Iran (Islamic Republic of)