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IRCT201312271674N10 IRCT 2014-04-12 Vice-Chancellery of Research and Technology, Shiraz University Of Medical Sciences Is oral tranexamic acid effective in reduction of blood loss during rhinoplasty? Effect of preoperative oral tranexamic acid on intraoperative bleeding during rhinoplasty: A Clinical Trial 2014-03-21 anticipated 50 Complete https://irct.ir/trial/1151 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 2 Rhinoplasty. Intervention 1: Drug is administered with dose of 1000 mg (two 500 mg tablets) orally with about 20 cc of water are given to the patient's study 2 hours before surgery. Intervention 2: The second group or control group received placebo with about 20 cc of water 2 hours before surgery.
public Hamid Reza Eftekharian
Shiraz University Of Medical Sciences, Shiraz Chamran Hospital, Chamran Blvd., Shiraz
Shiraz Iran (Islamic Republic of) 7183856793 +98 71 1648 3783 eftekharhr@sums.ac.ir Shiraz University Of Medical Sciences scientific Hamid Reza Eftekharian
Shiraz University Of Medical Sciences, Shiraz Chamran Hospital, Chamran Blvd., Shiraz
Shiraz Iran (Islamic Republic of) 7194815644 +98 71 1648 3783 eftekharhr@sums.ac.ir Shiraz University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria included: The patients with systemic disease and no history of drug use, and willingness to cooperate in this study are enrolledØ› Exclusion criteria included known allergy to the study drug, hepatic and renal dysfunction and lack of signed informed consent will be excluded. 16 years 40 years Both 00 00 Treatment - Drugs Treatment - Drugs Drug is administered with dose of 1000 mg (two 500 mg tablets) orally with about 20 cc of water are given to the patient's study 2 hours before surgery. The second group or control group received placebo with about 20 cc of water 2 hours before surgery. The amount of intraoperative bleeding. Timepoint: End of surgery. Method of measurement: Weight of the Gauze in the operating room for surgery with digital scale. Blood pressure and heart rate values. Timepoint: Preoperative, intraoperative and postoperative. Method of measurement: Vital signs monitoring device. Side effects of postoperative oral tranexamic acid. Timepoint: Postoperative in recovery room. Method of measurement: The nurse reported in the recovery. Agitation and postoperative shivering. Timepoint: Recovery room. Method of measurement: The nurse reported in the recovery. Vice-Chancellery of Research and Technology, Shiraz University Of Medical Sciences Approved 2010-09-23 Ethics committee Of Shiraz University Of Medical Sciences Shiraz University of Medical Sciences, Vice-Chancellery of Research and Technology, Zand Avenue, Shiraz Shiraz Iran (Islamic Republic of)