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IRCT201403061674N11 IRCT 2014-07-03 Vice-Chancellery of Research and Technology, Shiraz University Of Medical Sciences Thiamine ( Intravenous Vitamin B1) induced post–operative analgesia in maxillofacial surgery. Role of thiamine in the management of post–operative analgesia in maxillofacial surgery. 2014-08-23 anticipated 50 Complete https://irct.ir/trial/1152 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 2 Maxillofacial surgery. Intervention 1: Patients in the interventional group (first group) will be received an intravenous "Thiamine hydrochloride" 200 mg dissolved in Dextrose Water 5% via pump infusion bolus for 15 min. Intervention 2: Patients in the the second group will receive " placebo" as same bolus volume of " Dextrose Water 5% " in a 15-minute intravenous infusion.
public Hamid Reza Eftekharian
Shiraz University Of Medical Sciences, Shiraz Chamran Hospital, Chamran Blvd., Shiraz
Shiraz Iran (Islamic Republic of) 7194815644 +98 71 1624 0105 eftekharhr@sums.ac.ir Shiraz Chamran Hospital scientific Hamid Reza Eftekharian
Shiraz University Of Medical Sciences, Shiraz Chamran Hospital, Chamran Blvd., Shiraz
Shiraz Iran (Islamic Republic of) 7194815644 +98 71 1624 0105 eftekharhr@sums.ac.ir Shiraz Chamran Hospital Iran (Islamic Republic of) Inclusion criteria included: The patients with systemic disease and no history of drug use, and willingness to cooperate in this study are enrolled؛ Exclusion criteria included known allergy to the study drug, hepatic and renal dysfunction and lack of signed informed consent will be excluded. 16 years 40 years Both 00 00 Treatment - Drugs Treatment - Drugs Patients in the interventional group (first group) will be received an intravenous "Thiamine hydrochloride" 200 mg dissolved in Dextrose Water 5% via pump infusion bolus for 15 min. Patients in the the second group will receive " placebo" as same bolus volume of " Dextrose Water 5% " in a 15-minute intravenous infusion. Intensity of postoperative pain. Timepoint: Immediately after surgery to 12 hours after surgery. Method of measurement: VAS. Use of narcotic after surgery. Timepoint: To 12 hours after surgery. Method of measurement: Nursing reports. Post-operative complications of Thiamine. Timepoint: Immediately after surgery to 12 hours after surgery. Method of measurement: Nursing reports. Patient's level of satisfaction. Timepoint: Immediately after surgery to 12 hours after surgery. Method of measurement: poor (0), moderate (1), good (2), and excellent (3). Vice-Chancellery of Research and Technology, Shiraz University Of Medical Sciences Approved 2010-09-23 Ethics Committee of Shiraz University of Medical Sciences Shiraz University of Medical Sciences, Vice-Chancellery of Research and Technology, Zand Avenue, Shiraz Shiraz Iran (Islamic Republic of)