IRCT2012102311234N1 IRCT 2012-11-28 Vice Chancellor for Research,Tehran University of Medical Sciences Effects of Transcranial Direct Current Stimulation (tDCS) over Craving in abstinence methamphetamine user Online Transcranial DC Stimulation (tDCS) over the Dorsolateral Prefrontal Cortex and Cue Induced Craving in Methamphetamine Dependents: A double-blind, sham-controlled study 2012-07-22 anticipated 32 Complete https://irct.ir/trial/11531 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment. 2-3 Methamphetamine dependency. Intervention 1: Direct current was delivered from a battery-driven, constant current stimulator (ActivaDoseII. Iontophoresis Delivery Unit, P/N00148-Rev A, ActivaTek, Inc. Salt Lake City UT 84119 USA) and transferred by a pair of 5×7 (35cm2) electrodes. Electrodes were standard carbonic, covered with a normal saline socked sponge cases. Subjects were randomized to receive sham or anodal tDCS. In this study, intervention group received real tDCS. In this case, the anode electrode was placed on right Dorsolateral prefrontal cortex (rDLPFC) and cathode electrode was placed on the forehead above the left eye (Supraorbital). 2 mA current for 20 minimums was passed from patient's brain. In our study, washout period between 2 session interventions was at least 72-h, to avoid the potential of any carry-over effects due to previous stimulation. Intervention 2: In this study, control group received sham transcranial direct current stimulation(tDCS). For sham stimulation, the same methods of placing anode and cathode were used, however, the stimulator was ramped-up to 2 mA in 30s, then gradually ramped-down to 0 mA over the period of 1 minute, and then turned off but the electrodes were on the scalp for 20 minutes and subjects were not informed that the device is turned off.