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IRCT2012110611384N1 IRCT 2012-12-03 The Dean, College of Pharmacy, University of Baghdad Dopamine receptor in hypertension with Polycystic Kidney Disease Study the role of dopamine receptors on the structure and function of endothelial primary cilia in vitro and in vivo 2012-06-01 anticipated 30 Complete https://irct.ir/trial/11646 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment. 2-3 Adult Polycystic Kidney Disease. Intervention 1: Levodopa 50 mg capsule three times daily for 7 days; Domperidone 20 mg to reduce nausea used 30 minutes before Levodopa dose for 7 days. Intervention 2: Levodopa 100 mg capsule, three times daily for 7 days; Domperidone 20 mg to reduce nausea used 30 minutes before levodopa dose for 7 days. Intervention 3: control, placebo capsule three times daily for 7 days; domperidone 20 mg also used in this group to simulate drug group.
public Sarmed H. Kathem
Babalmoadhum 14026
Baghdad Iraq 009647901552609 sarmed.kathem11@utoledo.edu College of Pharmacy-University of Baghdad; College of Pharmacy-University of Toledo scientific Surya M. Nauli
3000 Arlington ave
Toledo United States 43614 001419383-1921 surya.nauli@utoledo.edu College of Pharmacy and Medicine, University of Toledo Iraq Iraq Inclusion criteria: adult type polycystic kidney disease with borderline hypertension; Control group inclusion criteria are essential borderline hypertension without any secondary cause. Exclusion criteria are: Pregnancy, lactation, diabetes mellitus, myocardial infarction, angina, arrhythmias, renal transplantation, renal failure, serum creatinin more than 3mg/dL, dialysis, sever hypertension, recieving antihypertensive drugs. 25 years 45 years Both Q61.2 Polycystic kidney, autosomal dominant Polycystic kidney, adult type Treatment - Drugs Treatment - Drugs Placebo Levodopa 50 mg capsule three times daily for 7 days; Domperidone 20 mg to reduce nausea used 30 minutes before Levodopa dose for 7 days Levodopa 100 mg capsule, three times daily for 7 days; Domperidone 20 mg to reduce nausea used 30 minutes before levodopa dose for 7 days control, placebo capsule three times daily for 7 days; domperidone 20 mg also used in this group to simulate drug group Blood Pressure. Timepoint: 0 hour, 2 hours, 7 days. Method of measurement: mercury sphygmomanometer. Serum Nitric Oxide. Timepoint: 0 hour, 7 days. Method of measurement: serum detection by Greiss reaction (colorimetric). Heart rate. Timepoint: 0 hour, 2 hour, 7 days. Method of measurement: radial pulse method. Assymetric dimethylarginine. Timepoint: 0 hour, 7 days. Method of measurement: serum samples by ELISA. Serum Creatinin. Timepoint: 0 hour, 7 days. Method of measurement: serum sample by ready made kit. Urea. Timepoint: 0 hour, 7 days. Method of measurement: serum sample by ready made kit. Calcium. Timepoint: 0 hour, 7 days. Method of measurement: serum sample by ready made kit. Sodium. Timepoint: 0 hour, 7 days. Method of measurement: serum sample by ready made kit. Potassium. Timepoint: 0 hour, 7 days. Method of measurement: serum sample by ready made kit. Albumin. Timepoint: 0 hour, 7 days. Method of measurement: serum sample by ready made kit. Alanine Aminotransferase. Timepoint: 0 hour, 7 days. Method of measurement: serum sample by ready made kit. Aspartate Aminotransferase. Timepoint: 0 hour, 7 days. Method of measurement: serum sample by ready made kit. Alkaline Phosphatase. Timepoint: 0 hour, 7 days. Method of measurement: serum sample by ready made kit. Total Bilirubin. Timepoint: 0 hour, 7 days. Method of measurement: serum sample by ready made kit. Body Mass Index. Timepoint: baseline. Method of measurement: Weight (kg)/Height (sequare meter). The Dean, College of Pharmacy, University of Baghdad Approved 2012-05-22 Ethics Committee of College of Pharmacy- graduate study committee Babalmouadhum 14026 Baghdad Iraq