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IRCT2013120111398N5 IRCT 2014-02-16 Research deputy, Iran University of Medical Siences The effect of clonidine on hemodynamic complications of laparoscopy Evaluation of effects oral clonidine premedication on perioperative hemodynamic response and postoperative pain of patients with controlled hypertension undergoing laparoscopic cholecystectomy 2012-03-20 anticipated 70 Complete https://irct.ir/trial/11659 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 3 Laparoscopic cholecystectomy. Intervention 1: In Intervention group: Patients received 0.2 mg oral Clonidine (CLONIDINE HCL 0.2MG TAB, Toliddaru, Iran) preoperatively. Intervention 2: In Placebo Group: Patients received placebo tablets in the same shape of the clonidine tablets preoperatively.
public Mohammad Reza Ghodraty MD.
Anesthesia Department, Firoozgar Hospital, Beh-Afarin St. Karim Khan Av.
Tehran Iran (Islamic Republic of) +98 21 8894 6762 m-ghodrati@tums.ac.ir mrghodrati@yahoo.com Iran University of Medical Sciences scientific Dr Mohammadreza Ghodrati,
Anesthesia Department, Firoozgar Hospital, Beh-Afarin St. Karim Khan Av.
Tehran Iran (Islamic Republic of) +98 21 8894 6762 m-ghodrati@tums.ac.ir mrghodrati@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: ASA grades II and III, both males and females, adult patients aged 18 to 65 years, with Controlled Hypertension (Systolic less than 140 and diastolic less than 90) scheduled Laparoscopic cholecystectomy surgeries. Exclusion criteria: Lack of patient consent, history of bronchial asthma, patients allergic to clonidine, hypertensive and diabetic patients, severe coronary insufficiency, recent myocardial infection, concomitant use of monoamine oxidase inhibitors, tricyclic antidepressants or opioids. 18 years 65 years Both K80.2 Calculus of gallbladder without cholecystitis Prevention Placebo In Intervention group: Patients received 0.2 mg oral Clonidine (CLONIDINE HCL 0.2MG TAB, Toliddaru, Iran) preoperatively. In Placebo Group: Patients received placebo tablets in the same shape of the clonidine tablets preoperatively. Mean arterial blood pressure. Timepoint: Before induction, in 1,5,10,15 and 20 minute after induction, and every 15 minute until the end of the operation. Method of measurement: Will be recorded by Automatic Hemodynamic Monitoring. Patient's pain intensity. Timepoint: Entrance to the recovery, 30, 60, 90 and 120 minutes postoperatively. Method of measurement: According to VAS rating score. Research deputy, Iran University of Medical Siences Approved 2013-06-01 Ethics committee of Tehran University of Medical Sciences Room 501, 5th Floor, Central Office of Tehran University of Medical Sciences, Keshavarz Bolvard Tehran Iran (Islamic Republic of)