IRCT2015072311399N2 IRCT 2015-08-04 Vice chancellor for research, Semnan University of Medical Sciences The Comparison of the effects of metformin and insulin in the treatment of hyperglycemia The Comparison of the effects of metformin and insulin in the treatment of hyperglycemia after coronary artery bypass surgery in non diabetic patients. 2015-08-23 anticipated 60 Complete https://irct.ir/trial/11672 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Condition 1: Hyperglycemia after coronary artery bypass surgery. Condition 2: Hyperglycaemia. Intervention 1: In the intervention group (1) or insulin group, patients will receive continuous insulin infusion according to the protocol of STS.After starting insulin infusion ,these patients’ blood glucose will be controlled per hour and according to their blood glucose level, the amount of insulin infusion will be continued.In this group blood glucose control interval will be every six hours after the stabilization of blood glucose. Then insulin infusion and six-hour blood glucose control will continue until the end of the third postoperative day (72 hours). Intervention 2: In the intervention group (2) or metformin group, the patients will receive metformin 500 mg twice a day and before the next dose of metformin, their blood glucose will be evaluated. If lactate is higher than 4/5 or 2 mmol higher than the previous response, takingmetformin will be stopped and the patient will be excluded.In these patients after starting metformintablet, their blood glucose will be controlled per hour and it will continue until the stabilization of blood glucose level.In this group the blood glucose interval control will be every six hours after the stabilization of blood glucose. Then, the prescription of metformin tablet of a dose of 500 mg twice a day and six-hour control of blood glucose until the end of the third postoperative day (72 hours) will continue.