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IRCT2014021611430N4 IRCT 2014-03-17 Infertility and recurrent abortion treatment center of Avicenna Efficacy of embryo culture on freezed embryos and pregnancy outcome Evaluation of efficacy of GM-CSF in embryo culture for freezed embryos in embryo development and pregnancy outcomes 2014-03-11 anticipated 80 Complete https://irct.ir/trial/11703 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 4 In vitro fertilization. In intervention group , embryos after thawing will cultured in medium with growth factor and in control group they will cultured in medium without growth factor. IN two groups will evaluate Blastocyst development and embryo quality..
public Zafardoust Simin
97 no.Yakhchal street, Shariati Street.
Tehran Iran (Islamic Republic of) 19419113194 +98 21 2264 4701 Sadeghi@avicenna.ac.ir s.zafardoost@avicenna.ac.ir Infertility and recurrent abortion of Avicenna scientific Dr Sadeghi Mohammad Reza
97 no.Yakhchal street, Shariati Street.
Tehran Iran (Islamic Republic of) 19419113194 +98 21 2264 4701 Sadeghi@avicenna.ac.ir S.Zafardoost@avicenna.ac.ir Infertility and recurrent abortion treatment center of Avicenna Iran (Islamic Republic of) Inclusion criteria: 1)Couples that undergoing treatment whit own gametes 2)women under 40 ears old 3)Women whit at least 4 good quality embryo after thawing(grade A) 4)Women that did not have more than 1 previous embryo transfer Exclusion criteria: 1)Cycles whit no PGD(Preimplantation genetic diagnosis) 2)Women whit no uterine anatomic disorder or hydrosalpinx no limit 42 years Female Z31.2 In vitro fertilization Treatment - Other In intervention group , embryos after thawing will cultured in medium with growth factor and in control group they will cultured in medium without growth factor. IN two groups will evaluate Blastocyst development and embryo quality. Development of embryos to blastocysts. Timepoint: 5 days after intervention. Method of measurement: Microscopic evaluation of embryos. Implantation rate. Timepoint: 5 weeks after intervention. Method of measurement: Vaginal ultrasonography. Clinical pregnancy rate. Timepoint: 6 weeks after intervention. Method of measurement: Vaginal ultrasonography. Quality of embryos. Timepoint: 5 days after intervention. Method of measurement: Microscopic evaluation of embryos. Beta HCG level. Timepoint: 19 days after intervention. Method of measurement: Blood sample evaluation. Evaluation of abortion under 12 weeks. Timepoint: 12 weeks after intervention. Method of measurement: History of patient. Multiple pregnancy. Timepoint: 5 weeks after intervention. Method of measurement: Vaginal ultrasonography. Infertility and recurrent abortion treatment center of Avicenna Approved 2014-01-14 Research center of Avicenna 97 no.Yakhchal street, Shariati Street. Tehran Iran (Islamic Republic of)