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IRCT2012121511738N2 IRCT 2016-05-17 Vice Chancellor for Research of Tabriz University of Medical Sciences Effect of N-Acetyl cysteine on the success rate of H.pylori eradication Effect of N-Acetyl cysteine on the success rate of H.pylori eradication 2016-04-01 anticipated 230 Complete https://irct.ir/trial/11904 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Helicobacter pylori. Intervention 1: the treatment group are pretreated with NAC groups underfor the 600 mg 2 times a day for a week and then standard triple therapy (amoxicillin 1000 mg 2 times a day, clarithromycin 500 mg two times daily and omeprazole 20 mg 2 times a day). Intervention 2: Control group treated with standard triple therapy (amoxicillin 1000 mg 2 times a day, clarithromycin 500 mg two times daily and omeprazole 20 mg 2 times a day) are placed.
public Dr.Korosh Masnadi Shirazi
Department of Gastroenterology, Imam Reza Hospital, Gate University, Tabriz, East Azarbaijan
Tabriz Iran (Islamic Republic of) +98 41 3337 3966 Masnadik@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Dr. Korosh Masnadi Shirazi
Department of Gastroenterology, Imam Reza Hospital, Gate University, Tabriz, East Azarbaijan
Tabriz Iran (Islamic Republic of) +98 41 3337 3966 MasnadiK@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients older than 20 years old, HP positive patients at the time of an injection molded pylori eradication indicated they have not previously received eradication regimen, the patients who have NAC in past month. Exclusion criteria: history of gastrectomy, gastric cancer includes adenocarcinoma, previous allergic reaction to antibiotics (amoxicillin and clarithromycin), NAC and proton pump inhibitors (omeprazole), pregnant and lactating women, concurrent severe illness, phenyl ketone Avery, taking antibiotics or NAC now or in the past month and is patient's dissatisfaction. 20 years no limit Both B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters Treatment - Drugs Treatment - Drugs the treatment group are pretreated with NAC groups underfor the 600 mg 2 times a day for a week and then standard triple therapy (amoxicillin 1000 mg 2 times a day, clarithromycin 500 mg two times daily and omeprazole 20 mg 2 times a day). Control group treated with standard triple therapy (amoxicillin 1000 mg 2 times a day, clarithromycin 500 mg two times daily and omeprazole 20 mg 2 times a day) are placed. The success rate of H pylori eradication regimen. Timepoint: One month after treatment. Method of measurement: Test. Vice Chancellor for Research of Tabriz University of Medical Sciences Approved 2016-02-20 Ethics Committee of Tabriz University of Medical Sciences Tabriz University of Medical Sciences, Golgasht Street, Tabriz Tabriz Iran (Islamic Republic of)