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IRCT2013060411763N8 IRCT 2013-09-12 Food Security Research Center Effect of vitamin D supplementation on inflammatory markers, liver function, lipid profile, body composition, and sonographic findings in patients with NAFLD Effect of vitamin D supplementation on inflammatory markers, liver function, lipid profile, body composition, and sonographic findings in patients with NAFLD 2012-06-20 anticipated 60 Complete https://irct.ir/trial/11921 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A non alcohlic fatty liver disease. Intervention 1: This randomized clinical trial will be conducted in parallel. The objective of this study is the low number of participants in this study, 60 patients with NAFLD are referred to the Medical Research Center for Gastroenterology.The consent of the individuals participating in the study will be made in the experimental group during the 10-week study, which included a week Pearl vitamin D supplements are vitamin D 50,000 IU receive.The control group during the 10 weeks, each week placebo in terms of shape, color is similar to vitamin D supplements. The study followed patients for vitamin D supplement use,Weekly basis with the individuals contacted by telephone and SMS reminders to be a supplement to these people. To assess the level of acceptance of 25-hydroxy vitamin D supplements Gyy the size of the trucks will be used to study. Intervention 2: Palcebo.
public mahdi foroughi
isfahan university medical science, school of nutrition
isfahan Iran (Islamic Republic of) 8174673461 +98 31 1523 6352 MFOROGHI38@YAHOO.COMASKARI@MUI.AC.IR food security research center scientific gholamreza askari
isfahan university medical science, school of nutrition
isfahan Iran (Islamic Republic of) 8174673461 +98 31 1792 2658 askari@mui.ac.ir isfahan university medical science, school of nutrition Iran (Islamic Republic of) Inclusion criteria were stable increases in AST and ALT greater than 50 U / L and metabolic syndrome, which includes waist circumference greater than 40 inches for men and greater than 35 inches for women, Triglycerides greater than or equal to 150 mg /dl, HDL less than 40 mg / dl for men and less than 50 mg/dl for women, Blood pressure greater than or equal to 85/135 mmHg, fasting blood glucose greater than or equal to 110 mg / dl. The participants in this study have not hepatitis C, B and Wilson disease and no history of chronic liver disease, a disease that affects the gallbladder and bile ducts. The absence of gestational, diabetes mellitus type 1 and 2, use of drugs affecting the levels of ALT (valproic acid, tamoxifen, HMG-COA reductase inhibitors, metformin, ACE 1 and ACER 1). They do not follow the diet and weight loss because weight loss effective vitamin d. Exclusion criteria included hospitalization, lack of cooperation in the study and with an acute illness. no limit no limit Both k76 Other diseases of liver Treatment - Drugs Placebo This randomized clinical trial will be conducted in parallel. The objective of this study is the low number of participants in this study, 60 patients with NAFLD are referred to the Medical Research Center for Gastroenterology.The consent of the individuals participating in the study will be made in the experimental group during the 10-week study, which included a week Pearl vitamin D supplements are vitamin D 50,000 IU receive.The control group during the 10 weeks, each week placebo in terms of shape, color is similar to vitamin D supplements. The study followed patients for vitamin D supplement use,Weekly basis with the individuals contacted by telephone and SMS reminders to be a supplement to these people. To assess the level of acceptance of 25-hydroxy vitamin D supplements Gyy the size of the trucks will be used to study Palcebo The severity of fatty liver using abdominal ultrasound at baseline and end of study. Timepoint: Baseline and 10 weeks after intervention. Method of measurement: ultrasound. AST and ALT liver enzymes. Timepoint: Baseline and 10 weeks after intervention. Method of measurement: Blood tests. Body composition. Timepoint: baseline and 10 weeks after intervention. Method of measurement: instrument body composition. FBS. Timepoint: baseline and 10 weeks after intervention. Method of measurement: blood test. Lipid profile. Timepoint: baseline and 10 weeks after intervention. Method of measurement: blood test. CRP. Timepoint: baseline and 10 weeks after intervention. Method of measurement: blood test. Food Security Research Center Approved 2012-06-09 isfahan university medical science isfahan isfahan Iran (Islamic Republic of)