]>
IRCT2014080211956N2 IRCT 2014-10-19 Mashhad University of medical Siences Effect of intravenous hydrocortisone in patients with septic shock Effect of intravenous hydrocortisone in patients with refractory septic shock admitted in Imam Reza hospital 2014-08-23 anticipated 160 Complete https://irct.ir/trial/12131 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Septic shock. Intervention 1: Hydrocortisone administration every 6 hours for 7 days in intervention group. Intervention 2: Placebo (normal saline solution 0.9%) administration every 6 hours for 7 days in control group.
public Dr. Azadeh Mahmoudi Gharaee
Department of Emergency Medicine, Imam Reza Hospital
Mashhad Iran (Islamic Republic of) +98 51 3852 5312 mahmoudia913@mums.ac.ir Mashhad University of Medical Sciences scientific Dr Morteza Talebi Deloei
Department of Emergency Medicine, Imam Reza Hospital
Mashhad Iran (Islamic Republic of) +98 51 3852 5312 talebidm@mums.ac.ir Department of Emergency Medicine, Mashhad University of Medical Sciences Iran (Islamic Republic of) All patients above eighteen who admitted in Imam Reza Hospital of Mashad with diagnosis of septic shock and do not respond to vasopressor therapy more than 60 minutes are included. Those who suffer from adrenal insufficiency before admission or had tuberculosis or had been treated with ketoconazole or estrogens are excluded. Those with no consent with the plan are also excluded 18 years 90 years Both R57.2 Septic shock Treatment - Drugs Placebo Hydrocortisone administration every 6 hours for 7 days in intervention group Placebo (normal saline solution 0.9%) administration every 6 hours for 7 days in control group Mortality in 28 days. Timepoint: During 28 days. Method of measurement: Death records. Response to vasopressor. Timepoint: The time that there is no need to vasopressor. Method of measurement: Normal central vein pressure (6-12 Cm H2O), mean arterial pressure more than 65 mmHg. Mashhad University of medical Siences Approved 2013-11-30 Mashhad University of medical sciences Ethics committee-Ghoreishi building- Daneshgah Ave. Mashhad Iran (Islamic Republic of)