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IRCT2014112611956N3 IRCT 2015-03-16 Mashhad University of Medical Sciences Comparing the effect of of ranitidine and pantoprazole on the occurrence of ventilated associated pneumonia ventilator_associated pneumonia Comparing the effect of of ranitidine and pantoprazole on the occurrence of ventilated associated pneumonia 2014-12-22 anticipated 180 Complete https://irct.ir/trial/12132 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A pneumonia. Intervention 1: First group(intervention): 90 patients; from the beginning until the end of hospitalization intravenous Ranitidine 50 mg will be given three times a day and after tolerating oral nutrition will be continued 150 mg twice a day. Intervention 2: Second group (control):90 patients; starting treatment with intravenous pantoprazole 40Mg twice a day from the beginning of hospitalization and will be continued until the releasing time. After tolerating oral nutrition pantoprazole 40mg oral will be given to patients through nasogastric tube (intracapsular granules are extracted and washed with 20 cc water through nasogastric tube).
public Dr Sara Rozmina
Emergency Department Office, Imam Reza Hospital,Razi Street
Mashad Iran (Islamic Republic of) +98 51 3852 5312 sararozmina@gmail.com Mashhad University of Medical Sciences scientific Dr Morteza Talebi Deloie
Emergency Department Office, Imam Reza Hospital
Mashhad Iran (Islamic Republic of) +98 51 3852 5831 talebidm@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Inclusion criteriona: hospitalized intubated patients in intensive care unit of Imam Reza hospital during the study. Exclusion criteria: patients showing allergic reactions to ranitidin and pantoprazol; patients with active lung disease before receiving these two drugs; patients with active gastrointestinal bleeding at the beginning of our study; immune compromised patients or the history of receiving antibiotics or any factor that changes the immune condition toward VAP. no limit no limit Both J18.9 Pneumonia, unspecified Treatment - Drugs Treatment - Drugs First group(intervention): 90 patients; from the beginning until the end of hospitalization intravenous Ranitidine 50 mg will be given three times a day and after tolerating oral nutrition will be continued 150 mg twice a day. Second group (control):90 patients; starting treatment with intravenous pantoprazole 40Mg twice a day from the beginning of hospitalization and will be continued until the releasing time. After tolerating oral nutrition pantoprazole 40mg oral will be given to patients through nasogastric tube (intracapsular granules are extracted and washed with 20 cc water through nasogastric tube). Decreased incidance of ventilator associated pneumonia in intubated patients under mechanical ventilation. Timepoint: End of stay in the ICU. Method of measurement: Diagnostic criteria for VAP are: new infiltration in CXR plus two criteria of these three criteria:1.fever higher than 38.5,2.leukocytes more than 100000,3.pus in suctioning the tracheal tube secretion.the final diagnosis for VAP is based on the culture of the tracheal tube secretion.the existence of more than 100000 bacterial colony count will be positive. Fever more than 38.5 degree. Timepoint: Every day. Method of measurement: Thermometer. Lekusytosis more than 10000. Timepoint: Every day. Method of measurement: CBC. Colony count more than 100000 in tracheal tube culture. Timepoint: Every day. Method of measurement: Tracheal tube specimen culture. New infiltration in CXR. Timepoint: Every week. Method of measurement: Chest X Ray. Mashhad University of Medical Sciences Approved 2014-11-01 Mashhad University of Medical Sciences Mashhad University of Medical Sciences, Daneshgah street Mashhad Iran (Islamic Republic of)