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IRCT2013010111976N1 IRCT 2013-02-10 Deputy of Research of Tabriz University of Medical Sciences Effect of propolis use on blood level of il-17 in ulcerative oral lichen planus patients. Effect of propolis use on blood level of il-17 in ulcerative oral lichen planus patients 2013-02-04 anticipated 30 Complete https://irct.ir/trial/12148 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A oral lichen planus. propolis capsule 500 mg daily for one month.
public Dr Reza Tavakoli Ataabadi
Tabriz- Golgasht street- Faculty of Dentistry- Oral Medicine Department
Tabriz Iran (Islamic Republic of) 5166614713 +98 41 1335 5965 drtavakolireza.dds@gmail.com Dental Faculty of Tabriz University of Medical Sciences scientific Dr Ali Taghavi Zonuz
Tabriz- Golgasht street- Faculty of Dentistry- Oral Medicine Department
Tabriz Iran (Islamic Republic of) 5166614713 +98 41 1335 5965 taghavia@tbzmed.ac.ir Dental Faculty of Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients with ulcerative oral lichen planus with clinical manifestations and histopathological criteria including: 1-Areas of hyper parkeratosis or hyper orthokeratosis, often with thickening of granular cell layer and saw-toothd appearance to the retepegs. 2-liquefaction degeneration or necrosis of basal cell layer. 3-sub epithelial band like infiltration of T lymphocyte and macrophage. Exclusion criteria: any factor that cause lichenoid reaction like as drug use or presence of amalgam restoration adjucent to lesions; any disease that suppresses immune system,such as HIV or Iv drug abuse,and any disease in which doing biopsy has medical complications; use of drug during one month ago for treatment of olp or use of antibiotic or corticosteroid or any drug that can suppress lymphocyte activity(for confidence that drugs don't change serum level of il-17); report of dysplasia or malignancy in patients pathology; history of dermal or digestive hypersensitivity to propolis; unwillingness to participate in study at any stages and report of side effects from patients or researchers. 18 years 70 years Both L-43 lichen planus Treatment - Drugs propolis capsule 500 mg daily for one month Serum level of il-17. Timepoint: At the begining of research-one month later. Method of measurement: Elisa kit (ebio science company). Size of lesions. Timepoint: At the beigining of the research-one month later. Method of measurement: Mesurment of lesion size at the begining of research with digital colis and then mark the changes by researcher in future follwing. Pain and burning sensation. Timepoint: At the beigining of the research-one month later. Method of measurement: VAS scale. Deputy of Research of Tabriz University of Medical Sciences Approved 2013-01-07 Research Deputy of tabriz university of medical sciences Tabriz-Golgasht street-university of medical sciences -central building no 2-3th floor. Tabriz Iran (Islamic Republic of)