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IRCT2015071012018N3 IRCT 2016-09-16 Qazvin University of Medical Science The effect of levothyroxine on ECT Induced Memory Impairment in bipolar patients The effect of levothyroxine on ECT Induced Memory Impairment in bipolar patients 2016-08-22 anticipated 48 Complete https://irct.ir/trial/12174 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. N/A BIPOLAR affective disorder. Intervention 1: tablet levothyroxine 0.1 mg daily fasting during ECT treatment. Intervention 2: Tablet Placebo(similar Levothyroxine) daily Fasting during ECT treatment.
public Dr Seyed Majid Hoseiny Hoshyar
22 Bahman Hospital Rah-ahan avenue Qazvin
Qazvin Iran (Islamic Republic of) +98 28 3336 9923 majidhooshyar@yahoo.com Qazvin University of Medical Science scientific Dr Seyed Majid Hoseiny Hoshyar
22 Bahman Hospital Rah-ahan avenue Qazvin
Qazvin Iran (Islamic Republic of) +98 28 3336 9923 majidhooshyar@yahoo.com Qazvin University of Medical Science Iran (Islamic Republic of) Inclusion criteria:Diagnosis of bipolar disorder based on SCID questionnaire that its persian validity and reliability is confirmedَ؛Presence of ECT indication is under recommendation of psychiatrist؛Age between 18-64؛consent letter of patient's parents.Exclusion criteria:Any contraindication of levothyroxine؛Comorbidity of substance or alcohol dependence؛Any organic brain disorder or mental retardation (based on history, physical exam and patient's records) or any cognitive impairment(MMSE<23) at begining of study؛ECT less than 6 session؛ECT induced delirium؛not using at least one of standard mood stabilizers (sodium valproate ,lithium carbonate or carbamazepin)؛use more than one of standard mood stabilizers (sodium valproate ,lithium carbonate or carbamazepin)؛use more than one convulsion in ECT in at least half of sessions؛siezure duration below 15 second in more than half of sessions؛siezure duration higher thant 3 minutes in even one session؛ 18 years 65 years Both F31 Bipolar affective disorder Treatment - Drugs Treatment - Drugs tablet levothyroxine 0.1 mg daily fasting during ECT treatment Tablet Placebo(similar Levothyroxine) daily Fasting during ECT treatment Memory impairment. Timepoint: Baseline and Then two weeks after completion of therapy ذغذ. Method of measurement: wecsler memory tese. Cognitin state. Timepoint: Baseline and Then two weeks after completion of therapy ذغذ. Method of measurement: mmse. Qazvin University of Medical Science Approved 2015-11-08 Qazvin University Of Medical Science Shahid Bahonar Blv Qazvin Iran Qazvin Iran (Islamic Republic of)