IRCT2014020812072N1 IRCT 2014-03-19 Isfahan University of Medical Sciences Citalopram in the Renal Colic Pain Relief Management Synergistic Effects of Citalopram and Morphine in the Renal Colic Pain Relief 2012-03-20 anticipated 90 Complete https://irct.ir/trial/12203 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Renal Colic. Intervention 1: control group : check VAS before drug injection then the patients recieved 5mg Morphine and placebo. every 20min patients recheck for pain sevrity and if they have severe pain, they recive another dose of 5mg Morphine. Intervention 2: intervention group : check VAS before drug injection then the patients recieved 5mg Morphine and 20mg Citalopram. every 20min patients recheck for pain sevrity and if they have severe pain, they recive another dose of 5mg Morphine and 20mg Citalopram.

public Mehrdad Esmailian MD

Isfahan Medical University

Isfahan Iran (Islamic Republic of) +98 31 1629 3482 m_esmailian@med.mui.ac.ir Isfahan University of Medical Sciences scientific Mehrdad Esmailian MD

Isfahan Medical University

Isfahan Iran (Islamic Republic of) +98 31 1629 3482 m_esmailian@med.mui.ac.ir Isfahan University of Medical Sciences Iran (Islamic Republic of) The inclusion criteria : an age range of 18-55; a clinical diagnosis of acute colicky pain; pain severity of 7-10 based on visual analogue scale (VAS) and patients’ written consent to participate in the study The exclusion criteria : pregnancy or suspected of being pregnant; contraindication in relation to taking morphine and citalopram based on drug catalog; a history of dependence on opioids or Selective serotonin re-uptake inhibitors; receiving an analgesic during a 6-hour period before presentation; peritonitis or peritoneal symptoms and signs; any disease preventing communication and patient’s decision to leave the study 18 years 55 years Both N23 Unspecified renal colic Treatment - Drugs Treatment - Drugs control group : check VAS before drug injection then the patients recieved 5mg Morphine and placebo. every 20min patients recheck for pain sevrity and if they have severe pain, they recive another dose of 5mg Morphine. intervention group : check VAS before drug injection then the patients recieved 5mg Morphine and 20mg Citalopram. every 20min patients recheck for pain sevrity and if they have severe pain, they recive another dose of 5mg Morphine and 20mg Citalopram. Renal Colic. Timepoint: every 20 min for 3 times. Method of measurement: Visual Analogue Scale. Pain severity. Timepoint: every 20 min for 3 times. Method of measurement: Visual Analogue Scale. Isfahan University of Medical Sciences Approved 2012-10-24 Isfahan Univercity of Medical Siences Isfahan Univercity of Medical Siences Isfahan Iran (Islamic Republic of)