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IRCT2013012012203N1 IRCT 2013-11-09 Vice Chancellor For Research,Ghzvin University Of Medical Science Effects of Alfentanil on Hemodynamic Changes due to Endotracheal Intubation in Elective Cesarean Section under General Anesthesia Effects of Alfentanil on Hemodynamic Changes due to Endotracheal Intubation in Elective Cesarean Section under General Anesthesia 2013-03-20 anticipated 50 Complete https://irct.ir/trial/12303 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Elective cesearean under general anesthesia. Intervention 1: in interventional group patint give 10 mic/kg alfentanil befor induction. Intervention 2: control group give the same volum of intervention group normal salin befor induction. DOI: 10.4103/0019-5049.170033 <br /> <br /> Background and Aims: Endotracheal intubation can produce severe maternal haemodynamic changes during caesarean sections under general anaesthesia. However, administration of narcotics before endotracheal intubation to prevent these changes may affect the Apgar score in neonates. This study was designed to evaluate the effect of intravenous alfentanil on haemodynamic changes due to endotracheal intubation in elective caesarean sections performed under general anaesthesia. Methods: Fifty parturients were randomly divided into two equal groups. Patients in the first group received alfentanil 10 μg/kg and in the second group received placebo intravenously 1 min before induction of anaesthesia for elective caesarean section. Haemodynamic parameters and bispectral index system (BIS) in mothers, peripheral capillary oxygen saturation (SpO 2 ) and Apgar score in the newborn were assessed. Results: Changes in systolic blood pressure were significant at 1, 5 and 10 min after intubation between two groups. Changes in diastolic blood pressure were significantly less in alfentanil group, 1 min after induction of anaesthesia and 1 min after endotracheal intubation. Mean heart rate at 1 min after induction and at 1 and 5 min after intubation also reduced significantly in this group. Conclusion: Alfentanil use was associated with decreases or minimal increases in maternal systolic and diastolic blood pressures and heart rate after endotracheal intubation.
public Nilofar Masoudi
Ghazvin University Of Medical Science,Navab Avenue,Ghazvin
Ghazvin Iran (Islamic Republic of) 3413996136 +98 28 1335 9557 nmasoudi@qums.ac.ir Ghazvin University Of Medical Science scientific nilofar masoudi
Ghazvin University Of Medical Science Ghazvin,Navab avenue,Gazvin
Ghazvin Iran (Islamic Republic of) 3413996136 +98 28 1335 9557 nmasoudi@qums.ac.ir Gazvin University Of Medical Science Iran (Islamic Republic of) inclusin criteria:patient age 20_40year; ASA 1 ; elective cesarean section. exclusin criteria:emergency ceserean; using antihypertensive drug; analgesic drug ;psychiatric drugs. 20 years 40 years Female Treatment - Drugs Placebo in interventional group patint give 10 mic/kg alfentanil befor induction control group give the same volum of intervention group normal salin befor induction Heart rate. Timepoint: evey 2 minute until delivery thenevery 5 minute to the end of surgery. Method of measurement: number of heart rate in one minute. Measuring systolic and diastolic blood pressur. Timepoint: evey 2 minute until delivery thenevery 5 minute to the end of surgery. Method of measurement: with cuff of blood pressure measuring. Bispecteral Index. Timepoint: every 2 minute unti delivery and then every 5 minute to the end of surgery. Method of measurement: level of consciousness. Saturation of neonate. Timepoint: after birth of neonet measuring. Method of measurement: level of oxygen in arterial blood measurig with pulse oxymetry. Apgar scor. Timepoint: 1 minute and 5 after birth. Method of measurement: level of consciousness in 1and 5min after birth. Awarness. Timepoint: after awaking in recovery. Method of measurement: time of maternal recall. Vice Chancellor For Research,Ghzvin University Of Medical Science Approved 2013-05-22 Ghazvin University Of Medical Science Ghazvin University Of Medical Science, Navab Avenue ,Ghazvin Ghazvin Iran (Islamic Republic of) Approved 2013-05-22 Gzvin University Of Medical Science Gzvin University Of Medical Science,Navab avenue Gazvin Iran (Islamic Republic of)