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IRCT2013012012204N1 IRCT 2013-12-09 Vice chancellor for research, Qazvin University of Medical Sciences The effect of Intrathecal Atropine to prevent Nausea & Vomiting after surgeries due to use Intrathecal Morphine in lower limb surgeries The effect of Intrathecal Atropine to prevent Nausea & Vomiting after surgeries due to use Intrathecal Morphine in lower limb surgeries 2013-03-05 anticipated 120 Complete https://irct.ir/trial/12310 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Spinal Anesthesia. Intervention 1: GroupB Spinal Anesthesia was induced using 2.5 cc of 0.5 % Hyperbaric Bupivacaine and 0.2 mg (1cc) of Intrathecal Morphine. In addition patients in group B received 1cc of saline 0.9%. Intervention 2: Group A Spinal Anesthesia was induced using 2.5 cc of 0.5 % Hyperbaric Bupivacaine and 0.2 mg (1cc) of Intrathecal Morphine. In addition patients in groupA received 0.1 mg (1cc) Intrathecal Atropine.
public Fatemeh Shima Hadipourzadeh
Qazvin University of Medical Sciences, Navab Street
Qazvin Iran (Islamic Republic of) +98 28 1333 6001 fhadipourzade@qums.ac.ir Qazvin University of Medical Sciences scientific Fatemeh Shima Hadipourzadeh
Qazvin University of Medical Sciences, Navab Street, Qazvin
Qazvin Iran (Islamic Republic of) +98 28 1333 6001 fhadipourzade@qums.ac.ir Qazvin University of Medical Sciences Iran (Islamic Republic of) Participants including major eligibility criteria: The patients aged from 40-70 years Participants excluding major eligibility criteria: Patients with history Neurologic disease and Neuromuscular; Diabetes Mellitus; Patients with Neuropathy Peripheral; Infection in site of injection; Sensitivity to Local Anesthesia; Patients with Vomiting and Nausea before surgery or receiving 48 hours before surgery Anti Vomiting and Nausea; Women in period of mense 40 years 70 years Both T41.3 local anaesthetics Placebo Treatment - Drugs GroupB Spinal Anesthesia was induced using 2.5 cc of 0.5 % Hyperbaric Bupivacaine and 0.2 mg (1cc) of Intrathecal Morphine. In addition patients in group B received 1cc of saline 0.9%. Group A Spinal Anesthesia was induced using 2.5 cc of 0.5 % Hyperbaric Bupivacaine and 0.2 mg (1cc) of Intrathecal Morphine. In addition patients in groupA received 0.1 mg (1cc) Intrathecal Atropine Incidence of Vomiting and Nausea. Timepoint: Incidence of Nausea and Vomiting were studied in patients within 24 hours after injection of Atropine: Hourly up to 6 hours, Then 6 hours later and Finally 12 hours later. Method of measurement: With checklist: Mild; Moderate; Severe. Heart Rate. Timepoint: 3,5,10,15 Minutes after Spinal Anesthesia with receiving Atropin Interathecal. Method of measurement: Heart Rate per minute. Blood Pressure. Timepoint: 3,5,10,15 Minutes after Spinal Anesthesia with receiving Atropin Intrathecal. Method of measurement: Blood volume pump by heart. With out pain period. Timepoint: Intrathecal Morphine-Induced Analgesia was studied in 2 hours intervals for 12 hours after injection. Method of measurement: With checklist. Vice chancellor for research, Qazvin University of Medical Sciences Approved 2013-02-27 Ethics Comitia Qazvin University of Medical Sciences Qazvin University of Medical Sciences, Navab Street, Qazvin Qazvin Iran (Islamic Republic of)