IRCT201312271743N12 IRCT 2014-01-07 Research center for behavioral disorders and substance abuse, Hamadan university of medical sciences Brain-Derived Neurotrophic Factor level in Depressive patients Evaluation of the effectc of the synchronised exercise and electroconvalsive therapy on serum brain neurotherupic factor in drug resistance depressive patient 2013-01-01 anticipated 60 Complete https://irct.ir/trial/1251 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Health service research. N/A Major Depressive Disorder. Intervention 1: Electero Convulsive Therapy+ antidepressant drug. Intervention 2: exercise +antidepressant. Intervention 3: Antidepressant drug.

public Mohammad Haghighi

Honarestan Str.

Honarestan Str

Hamadan Iran (Islamic Republic of) +98 81 1827 1066 haghighi@umsha.ac.ir Research center for behavioral disorders and substance abuse, Hamadan university of medical sciences Iran (Islamic Republic of) Inclusive Criteria 1. Patients with unipolar major depressive disorder admitted in one of the psychiatric wards of Farshchian Hospital 2. Aged of 18-40 years 3. No systemic diseases such as diabetes, hypertension, epilepsy and etc 4. No history of alcohol abuse or other illegal substances 5. Patient’s informed consent Exclusive Criteria 1. Incidence of uncontrollable somatic condition 2. Patient’s unwillingness to continue participation 18 years 40 years Both F32 Depressive episode Treatment - Drugs Treatment - Drugs Treatment - Drugs Electero Convulsive Therapy+ antidepressant drug exercise +antidepressant Antidepressant drug Severity of symptoms of Depression. Timepoint: Baseline and 4 weeks after treatment. Method of measurement: Hamiltone Depression scale. Level of Brain-derived neurotrophic factor in serum. Timepoint: Baseline and 4 weeks after treatment. Method of measurement: ELISA. Research center for behavioral disorders and substance abuse, Hamadan university of medical sciences Approved 2009-05-05 Hamadan University of Medical Sciences Fahmideh str. Hamadan Iran (Islamic Republic of)