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IRCT2013022712644N1 IRCT 2013-09-15 Vice chancellor for research Shiraz University of Medical Sciences Effect of hyaluronic acid on vaginal atrophy in postmenopausal women The Comparison of the effects of hyaluronic acid and conjugated estrogen vaginal cream (Prmarin) on vaginal atrophy in menopausal women referred to selected clinics affiliated to Shiraz university of medical sciences, 1391 2013-08-19 anticipated 56 Complete https://irct.ir/trial/12680 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Vaginal atrophy. Intervention 1: Conjugated estrogen vaginal cream drug (Prmaryn) to a group of patients / eight weeks / two weeks remaining in the first row and the same dose twice a week for six weeks. Intervention 2: Hyaluronic acid vaginal cream medication to a group of patient / eight weeks.
public Tayebe Davari Dehpiri
College of Nursing and Midwifery, Namazi
Shiraz Iran (Islamic Republic of) 7193613119 +98 71 1647 4254 davarit@sums.ac.ir College of Nursing and Midwifery, Shiraz scientific Azam Jokar
College of Nursing and Midwifery, Namazi
Shiraz Iran (Islamic Republic of) 7193613119 +98 71 1647 4254 jokarhs@yahoo.com College of Nursing and Midwifery, Shiraz Iran (Islamic Republic of) Major inclusion criteria: Married women past menopause who have symptoms؛Non-Smoking؛ The use of drugs such as Heparin anticoagulants؛ Vaginal dryness and moderate to severe pain in the area during intercourse. (measured by visual criteria)؛ Do not use vaginal medications, hormonal and non-hormonal treatment for 30 days before؛ No history of known or suspected hormone-dependent diseases such as (breast cancer, cases of unexplained vaginal bleeding, acute Phlebitis or Thromboembolic disorders associated with estrogen and ...) Major exclusion criteria: Need to cure vaginal infection in primary screening for Pap smear؛ Sensitivity (rash, erythema, inflammation, ...) to the drug or its ingredients؛ Lack of desire to continue working 45 years 65 years Female N95.2 Senile (atrophic) vaginitis Treatment - Drugs Treatment - Drugs Conjugated estrogen vaginal cream drug (Prmaryn) to a group of patients / eight weeks / two weeks remaining in the first row and the same dose twice a week for six weeks. Hyaluronic acid vaginal cream medication to a group of patient / eight weeks Maturity of vagina. Timepoint: Before and after eight weeks (end of intervention). Method of measurement: Calculate the percentage of cells in pap smear. Vaginal PH. Timepoint: Before and after eight weeks (end of intervention). Method of measurement: By PH meter strips. Vaginal dryness. Timepoint: Before and after the intervention. Method of measurement: VAS. Vaginal itching. Timepoint: Before and after the intervention. Method of measurement: VAS. Urine incontinence. Timepoint: Before and after the intervention. Method of measurement: VAS. Dyspareunia. Timepoint: Before and after the intervention. Method of measurement: VAS. Vice chancellor for research Shiraz University of Medical Sciences Approved 2013-08-19 Ethics Committee of Shiraz University of Medical Sciences Shiraz University of Medical Sciences, Zand Street Shiraz Iran (Islamic Republic of)