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IRCT2013030312689N1 IRCT 2013-08-02 Vice chancellor for research, Ahvaz Jondishapur University Of Medical Sciences effect of soymilk intake on inflammatory markers and oxidative stress Comparison of the effects of soy milk and cow's milk intake on the levels of inflammatory markers, proinflammatory cytokines and oxidative stress in patients with rheumatoid arthritis 2012-04-20 anticipated 30 Complete https://irct.ir/trial/12712 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Crossover, Purpose: Supportive. 2 Rheumatoid arthritis. Intervention 1: intervention group: daily consumption of 200 ml calcium-fortified soy milk (1% fat) for 4 weeks. produced by Soya Sun Company, in Iran. Intervention 2: control group: daily consumption of 200 ml cow's milk (1.5% fat) for 4 weeks. produced by Mihan-Dairy Company, in Iran.
public Razieh Choghakhori
Ahvaz Jondishapur University of Medical Sciences, Golestan Ave. Ahvaz
Ahvaz Iran (Islamic Republic of) +98 61 1373 8254 choghakhori.r@ajums.ac.ir School of Paramedicine, Ahvaz Jondishapur University Of Medical Sciences scientific Majid Mohammadshahi
Ahvaz Jondishapur University Of Medical Sciences, Golestan Ave. Ahvaz
Ahvaz Iran (Islamic Republic of) +98 61 1373 8254 shahi334@gmail.com School of Paramedicine, Ahvaz Jondishapur University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: 18-65 years old patient who have Rheumatoid Arthritis according to revised American Rheumatism Association criteria and Rheumatologist diagnosis. The type and dose of drug medication remain constant since 1 month prior and during of the study. Exclusion criteria: Patients who have chronic disease such as diabetes, cardiovascular, hepatic, kidney, gastrointestinal diseases, and severe infection. Smoking, alcohol consumption, use of dietary supplements and having allergy to soy products or cow’s milk. 18 years 65 years Both M05 Seropositive rheumatoid arthritis Treatment - Other Treatment - Other intervention group: daily consumption of 200 ml calcium-fortified soy milk (1% fat) for 4 weeks. produced by Soya Sun Company, in Iran. control group: daily consumption of 200 ml cow's milk (1.5% fat) for 4 weeks. produced by Mihan-Dairy Company, in Iran. TNF-α. Timepoint: at baseline and end of each intervention. Method of measurement: ELISA. IL-1. Timepoint: at baseline and end of each intervention. Method of measurement: ELISA. Hs-CRP. Timepoint: at baseline and end of each intervention. Method of measurement: ELISA. IL-6. Timepoint: at baseline and end of each intervention. Method of measurement: ELISA. Adiponectin. Timepoint: at baseline and end of each intervention. Method of measurement: ELISA. Leptin. Timepoint: at baseline and end of each intervention. Method of measurement: ELISA. RF. Timepoint: at baseline and end of each intervention. Method of measurement: Nephlometry. MDA. Timepoint: at baseline and end of each intervention. Method of measurement: Spectrophotometric. Blood Pressure. Timepoint: at baseline and end of each intervention. Method of measurement: Blood Pressure Monitor. Weight. Timepoint: at baseline and end of each intervention. Method of measurement: digital scale. Vice chancellor for research, Ahvaz Jondishapur University Of Medical Sciences Approved 2012-03-03 Ethics Committee of Ahvaz Jondishapur University Of Medical Sciences Jondishapur University Of Medical Sciences, Golestan Ave. Ahvaz Ahvaz Iran (Islamic Republic of)