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IRCT2015122212789N12 IRCT 2016-02-08 Vice Chancellor for Research ,Kurdistan University of Medical Sciences The effect of topical nitroglycerin 0.2% on anal pain reduction Comparing the effect of topical nitroglycerin 0.2% with placebo on pain severity reduction in patients with proctalgia fugax 2014-05-22 anticipated 40 Complete https://irct.ir/trial/12800 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Proctalgia fugax. Intervention 1: Intervention Group: To use nitroglycerin 0.2% ointment as much as a cherry core 3 times a day (every 8 hours) on pain site and intra anal for 2 weeks. Intervention 2: Control Group: To use the eucerin (placebo) as much as a cherry core 3 times a day (every 8 hours) on pain site and intra anal for 2 weeks.
public Masomeh Allahmoradi
Tohid Hospital, Basij Sq., Geriashan St., Sanandaj, Iran
Sananadaj Iran (Islamic Republic of) +98 87 3323 1754 masuume1633@gmail.com Kurdistan University of Medical Sciences scientific Dr. Kambiz Yazdanpanah
Tohid Hospital, Basij Sq., Geriashan St., Sanandaj, Iran
Sananadaj Iran (Islamic Republic of) +98 87 3323 1754 kyazdan4@yahoo.com Kurdistan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria including: 1. Consent to participate in the study 2. Patients with recurrent episodes of severe pain localized in the lower rectum and anus area, and the episodes of pain lasting a few seconds up to 20 minutes and there was no pain between episodes. Exclusion criteria including: 1. Any proved pathology during clinical history, physical examination and rectosigmoidoscopy in anorectal including (Hemorrhoids, ischemia, anal abscess, anal fissure, rectocele, malignancy, inflammation, anal prolapsed). 2. History of trauma, urinary tract infection, surgery and hysterectomy in recent 6 months 3. Associated symptoms (fever, change in stool consistency, anemia, anal secretions, abdominal pain, weight loss and rectal bleeding). 4. History of heart and neurological disease and aortic stenosis 5. History of hypotension 6. Chronic proctalgia 7. Unwillingness to continue participating in the study 8. Single rectal ulcer 18 years 80 years Both K59.4 Anal spasm Treatment - Drugs Treatment - Drugs Intervention Group: To use nitroglycerin 0.2% ointment as much as a cherry core 3 times a day (every 8 hours) on pain site and intra anal for 2 weeks. Control Group: To use the eucerin (placebo) as much as a cherry core 3 times a day (every 8 hours) on pain site and intra anal for 2 weeks. Pain severity. Timepoint: The second week, three months and six months after treatment. Method of measurement: Visual Analog Scale. The repetition of pain. Timepoint: The second week, three months and six months after treatment. Method of measurement: questionnaire. Vice Chancellor for Research ,Kurdistan University of Medical Sciences Approved 2015-05-05 Ethics Committee of Kurdistan University of Medical Sciences Kurdistan University of Medical Sciences, Pasdaran St., Sanandaj, Iran Sanandaj Iran (Islamic Republic of)