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IRCT2016103012789N13 IRCT 2016-12-04 Vice Chancellor for Research of Kurdistan University of Medical Sciences Comparing the effect of oxytocin alone versus oxytocin plus intravenous and oral propranolol on labor progression Comparing the effect of oxytocin alone versus oxytocin plus intravenous and oral propranolol on labor progression 2016-04-20 anticipated 123 Complete https://irct.ir/trial/12801 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Induction and Promotion of labor. Intervention 1: Intervention group oxytocin alone with dose 2 mIU/min which increase every 15 min. Intervention 2: Intervention group oxytocin plus intravenous propranolol, oxytocin with dose 2 mIU/min which increase every 15 min and propranolol 2 mg/ml IV. Intervention 3: Intervention group oxytocin plus oral propranolol, oxytocin with dose 2 mIU/min which increase every 15 min and propranolol 20 mg oraly.
public Dr. Narjes Marjani
Besat Hospital, Keshavarz St., Mardokh Cross Road, Sanandaj, Iran
Sanandaj Iran (Islamic Republic of) +98 87 3328 8119 melica313@yahoo.com Kurdistan University of Medical Sciences scientific Dr. Fariba Farhadifar
Besat Hospital, Keshavarz St., Mardokh Cross Road, Sanandaj, Iran
Sanandaj Iran (Islamic Republic of) +98 87 3328 8119 sima_homa@yahoo.com Kurdistan University of Medical Sciences Iran (Islamic Republic of) Inclusion Criteria: Nulliparity, singleton, cephalic presentation, fetal heart rate between 120 to 160 beats per minute, approximate weight of 2,500 to 4,000 (by examination or ultrasound), the maternal heart rate between 60 to 130 beats per minutes. Exclusion Criteria: CPD, any history of previous surgery on the uterus, fetal distress, the risk of macrosomia or polyhydramnius, SBP≤100, PR≤60, PR≥130 min, any history of cardiopulmonary disease, metabolic disease of mother or taking medicine for any illness by mother. 18 years 45 years Female O80.0 Spontaneous vertex deliveryr Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group oxytocin alone with dose 2 mIU/min which increase every 15 min Intervention group oxytocin plus intravenous propranolol, oxytocin with dose 2 mIU/min which increase every 15 min and propranolol 2 mg/ml IV Intervention group oxytocin plus oral propranolol, oxytocin with dose 2 mIU/min which increase every 15 min and propranolol 20 mg oraly The duration of phases of labor. Timepoint: From the intervention to delivery. Method of measurement: vaginal exam. Pregnancy ending in caesarean section. Timepoint: After the second period of injection. Method of measurement: Based on the indications for cesarean section. Vice Chancellor for Research of Kurdistan University of Medical Sciences Approved 2016-02-20 Ethics Committee og Kurdistan University of Medical Sciences Pasdaran St.,Kurdistan University of Medical Sciences, Sanandaj, Iran Sanandaj Iran (Islamic Republic of)